ʻO ka hope ... ka ʻike ʻana i ke kumu o ka maʻi o Alzheimer

ʻO ka hope ... ka ʻike ʻana i ke kumu o ka maʻi o Alzheimer

Ua hōʻike nā mea noiʻi mai ke Kulanui o Kaleponi i kahi noiʻi e hiki ke kumu o ka maʻi Alzheimer ma muli o ka lohi o ka hiki o nā cell e hoʻomaʻemaʻe iā lākou iho, e like me ka nūpepa Pelekane, "Daily Mail".

Ua hoʻohui ʻia ka haʻawina ua ʻike ʻia ka lohi i ka poʻe ma luna o 65 mau makahiki, ʻo ia ke kumu o ka hōʻiliʻili maikaʻi ʻole i ka lolo.

autophagy

ʻO ka lohi, ʻike ʻia ʻo autophagy, hiki ke kumu ma muli o ka hoʻokē ʻai ʻana, kahi i loaʻa ʻole ai i nā cell i ka nui o ka protein mai ka meaʻai a ke kanaka, a hoʻopiha lākou i ka hakahaka ma ka hana hou ʻana i nā protein i loko o nā keena.

ʻO Ryan Julian, he polopeka o ke kemika ma ke Kulanui o Kaleponi, nāna i alakaʻi i ke aʻo ʻana, ua ʻōlelo ʻia ua hoʻāʻo ʻia nā lāʻau lapaʻau e hoʻomaikaʻi i ka autophagy, a inā ʻo ia ke kumu o ka maʻi o Alzheimer, hiki iā mākou ke ʻike i kahi lāʻau lapaʻau hiki ke pale i ka maʻi. kokoke e hiki mai ana.

"Inā ʻo ka lohi i ka autophagy ke kumu kumu, a laila ʻo nā mea e hoʻonui ai e loaʻa i kahi hopena maikaʻi a kūʻē," i hoʻohui ai ʻo ia.

Eia naʻe, ua wehewehe ʻo ia ma kahi ʻōlelo, "Ma kahi o 20% o ka poʻe i loaʻa i nā plaques, akā ʻaʻohe hōʻailona o ka dementia. Me he mea lā ʻaʻole ʻo nā kiʻi pena ke kumu. "

Wehewehe

A ua hiki iā ia a me kāna mau hoa hana ke wehewehe i ka maʻi ma ka nānā ʻana i nā protein i loko o ka lolo.

I kēia manawa, ua hoʻomaka ka hui i ke aʻo ʻana ma ka nānā ʻana i nā proteins tau, i ʻike ʻia he ʻano ʻino i loko o ka lolo o ka poʻe me ka maʻi Alzheimer.

ʻO nā protein Tau ke kōkua i ka hoʻopaʻa ʻana i ka iwi o loko o nā pūnana aʻalolo, ʻike ʻia hoʻi ʻo neurons, i loko o ka lolo.

Akā ʻoiai he paʻakikī ke ʻike ʻia, ʻo ke ʻano like ʻole o ka tau i hiki ai i nā ʻepekema ke hoʻokaʻawale i nā poʻe i hōʻike ʻole i nā hōʻailona o waho o ka dementia mai ka poʻe i hana.

Nā mea isomer

Ke nānā nei ka lab o Julian ma ke kulanui i nā ʻano ʻano like ʻole i hiki i kahi mole hoʻokahi ke lawe, i kapa ʻia ʻo isomers, ʻo ia hoʻi i kōkua i ke kuhikuhi ʻana iā lākou i ka mea hewa.

"ʻO ka isomer ka mole like me kahi ʻano ʻekolu-dimensional orientation mai ka kumu mua," wahi a Julian.

Eia hou, ua nānā ka hui i nā protein a pau i loko o nā laʻana lolo i hāʻawi ʻia.

Ua hōʻike ʻia ʻo ka poʻe i kūkulu ʻia ka lolo akā ʻaʻole ka dementia he tau maʻamau, ʻoiai ua loaʻa kahi ʻano ʻokoʻa o ka tau i ka poʻe i loaʻa i ka maʻi palaka a i ʻole ke kuʻekuʻe wāwae a me ka dementia.

Eia kekahi, ʻo ka hapa nui o nā protein i loko o ke kino he hapa-ola ma lalo o 48 mau hola, akā inā ʻike ʻia lākou e noho mau, hiki ke hoʻololi ʻia kekahi o nā amino acids i kahi isomer.

Ua hōʻike ʻia ua ʻike ʻia ka maʻi Alzheimer e Kauka Alius Alzheimer i ka makahiki 1906, nāna i ʻike i nā loli o ka lolo o kahi wahine i make i ka maʻi noʻonoʻo ʻokoʻa.

Hoʻomaʻamaʻa pinepine nā kauka i ka maʻi o Alzheimer ke ʻike lākou i kahi hui ʻana o nā pā amyloid a me nā neurofibrillary tangles, me nā ana.

Ua ʻike ʻia ka hana ʻino ʻana i ka maʻi o Alzheimer, ʻo ia hoʻi ʻelua ʻano protein: ʻo kekahi i kapa ʻia ʻo amyloid, nona nā waihona i hana i nā plaques a puni nā cell lolo, a ʻo kekahi i kapa ʻia ʻo tau, e hana ana i nā kuʻekuʻe i loko o nā pūpū lolo.

ʻO nā helu cosmic kaulana a me ko lākou pilina me ka ʻoiaʻiʻo