Hiki i ka hoʻoikaika kino ke hoʻonui i ka paʻakikī o ke kūlana olakino

Hiki i ka hoʻoikaika kino ke hoʻonui i ka paʻakikī o ke kūlana olakino

ʻO kekahi o nā hōʻailona maʻamau o ka wā lōʻihi COVID-19 ʻo ia ka manaʻo e komo i ka hoʻomaʻamaʻa koʻikoʻi, kahi e hōʻeha ai i ke ʻano.

ʻAʻole i kaupalena ʻia ka hopena lōʻihi o ka maʻi Corona i ka hōʻemi ʻana i ka hiki o ke kanaka e hoʻomaʻamaʻa, akā ʻike pinepine ʻia nā hōʻailona ākea i nā lā ma hope o nā hoʻomaʻamaʻa aʻo ʻana, a ua kapa nā mea noiʻi i kēia ʻano "post-exertional malaise" (PEM), ka mea. he mea ano e.

Nā wehewehe physiological a me nā kumu

Wahi a ka mea i paʻi ʻia e ka New Atlas pūnaewele, e hōʻike ana i ʻelua mau noiʻi i paʻi ʻia nā hopena i loko o nā puke moʻolelo ERJ Open Research and Nature Communications, i ka hapa nui o nā hihia hoʻoponopono, pono ka hoʻoikaika kino, a i ka wā e ʻeha ai ka mea maʻi i ka hoʻomaʻamaʻa ʻana, ʻike pinepine ʻia ka physiological. wehewehe, ʻoiai ʻaʻole maikaʻi ka hana ʻana o ka puʻuwai a i ʻole ka māmā, a i ʻole ka lōʻihi o ka maʻi i alakaʻi ʻia i kahi ʻano deconditioning kino kahi e nāwaliwali mau ai ke kino.

Akā i nā hihia he nui o ka COVID-19 lōʻihi, ʻaʻohe hōʻailona maopopo e wehewehe ana i nā kapu hoʻoikaika kino. he wā lōʻihi o ka maʻi.

ʻOiai ʻaʻole kuhikuhi koke nā hopena i nā hoʻonā, hōʻoia lākou i nā hihia o ka hoʻomaʻamaʻa lōʻihi e pili ana i ka maʻi Corona he kumu physiological.

Ka ho'āʻo hoʻoikaika kino puʻuwai

ʻO ka hoʻāʻo kuʻuna loa o ka hiki kino kino o ka mea maʻi, ua kapa ʻia ʻo ia ka hoʻomaʻamaʻa cardiopulmonary exercise testing (CPET). Hoʻonoho ʻia ka mea maʻi ma luna o kahi kaʻa hoʻoikaika kino a nānā nā kauka i ka puʻuwai puʻuwai, saturation oxygen, a me ka ʻikepili electrocardiogram.

No nā maʻi maʻi coronavirus lōʻihi, hoʻihoʻi ka hoʻokolokolo CPET i nā hopena maʻamau. ʻOiai nā palena kūpono i ka hoʻoikaika kino e like me ka pōkole o ka hanu, hōʻike pinepine kēia mau maʻi i nā pae oxygen maʻamau a me ka hana naʻau olakino.

ʻO ka hoʻoikaika kino puʻupuʻu

Ua alakaʻi kahi hui o nā mea noiʻi ma ke Kulanui ʻo Yale i kahi noiʻi e pili ana i kahi hui o nā maʻi maʻi coronavirus lōʻihi i loaʻa kahi hoʻokolohua CPET hou, i kapa ʻia ʻo iCPET a i ʻole invasive cardiopulmonary exercise test, ʻoi aku ka paʻakikī ma mua o ka hoʻāʻo CPET maʻamau. Ma waho aʻe o nā kaʻina hana CPET maʻamau, ua hoʻokomo ʻia nā catheters ʻelua kaomi i loko o nā aʻa o nā maʻi e hana ana i kēia hoʻokolohua, e ʻae i ka nānā hou ʻana i ka hopena o ka hoʻoikaika kino ma nā ʻiʻo a me nā kīʻaha koko.

ʻO ka wehe ʻana o ka oxygen systemic

He mea kupanaha nā hopena, ʻaʻohe pilikia i ʻike ʻia ma ke ʻano o ka hana ʻana o ka puʻuwai a i ʻole ka māmā, akā ua hōʻike lākou i nā mea ʻino i ke ʻano o ke kino o ke kino e lawe ai i ka oxygen. Hoʻokaʻawale ʻia ʻo Dysfunction ma ke ʻano he impaired systemic oxygen extraction pEO2.

Ua wehewehe ʻo Peter Kahn, ka mea noiʻi alakaʻi o ke aʻo ʻana, ua ʻike ʻia "ʻoiai ʻo ka puʻuwai e puhi ana i ke koko oxygenated i hoʻolako ʻia e nā māmā me ka lawa o ka oxygen, ua hoʻopilikia ʻia ka unuhi ʻana o ka oxygen mai nā ʻiʻo o ke kino i nā maʻi i hōʻike i nā hōʻailona. o ka hoʻomaʻamaʻa ʻole. " Sports ma hope o Covid." Akā ʻaʻole hiki ke noʻonoʻo pono i ke kumu a pehea i hana ʻia ai kēia, ʻoiai ua kuhikuhi nā mea noiʻi i kekahi mau wehewehe kūpono no kēia ʻano maʻamau.

Manaʻo ka poʻe noiʻi o ke aʻo ʻana "hiki ke hoʻopili ʻia ka pEO2 ma muli o ka hiki ʻole o nā moena vascular non-exercise e hoʻopaʻa pono i ka vasoconstriction a i ʻole ke kahe ʻana o ke koko ʻiʻo, a i ʻole ka lawa ʻole o ka capillary diffusion i mitochondria."

Hōʻike hoihoi

ʻO kahi haʻawina, i paʻi ʻia ma ka puke pai Nature Communications, i alakaʻi ʻia e kahi hui ʻepekema ma ke Kulanui o Amsterdam, hāʻawi i nā ʻōlelo hoihoi e pili ana i nā mea e hiki mai ana. ʻIke ʻia ka pane e pili ana i ka mitochondria, nā mea kanu mana liʻiliʻi e hoʻoikaika ai i nā cell pākahi.
ʻO ka hoʻokolohua kūʻokoʻa loa o ke Kulanui o Amsterdam me kahi hui o nā maʻi maʻi coronavirus lōʻihi a me kahi pūʻulu mālama olakino. Ua hoʻopau ka poʻe noiʻi i kahi hoʻāʻo kaʻa kaʻa koʻikoʻi, e hāʻawi ana i nā hōʻailona koko a me nā ʻiʻo ʻiʻo i hoʻokahi pule ma mua a hoʻokahi lā ma hope o ka hoʻāʻo.

Nā mea ʻino i loko o ka ʻiʻo ʻiʻo

Ua ʻōlelo ʻo Rob West, kahi mea noiʻi i komo i ka noiʻi, ua ʻike ʻia ka metabolism maikaʻi ʻole a me nā hōʻailona o ka pōʻino nui o ka ʻiʻo i loaʻa i nā mea maʻi Covid no ka manawa lōʻihi ma hope o ka hoʻoikaika ikaika. ʻO ka mea nui paha, ua hōʻike nā hopena i ka hoʻomaʻamaʻa koʻikoʻi i kumu maoli i ka mitochondrial dysfunction i loko o nā ʻiʻo ʻiʻo, e wehewehe paha i ke kumu o ka poʻe maʻi lōʻihi-Covid i ʻoi aku ka maikaʻi o ka lā ma hope o ka hoʻoikaika kino.

"Ua ʻike mākou i nā ʻano like ʻole i ka ʻiʻo ʻiʻo o ka poʻe maʻi," wehewehe ʻo Foust. "Ma ka pae cellular, ʻike mākou i ka mitochondria muscle, i ʻike ʻia ʻo nā hale mana o ka cell, ʻoi aku ka maikaʻi o ka hana a hoʻemi i ka ikehu mai nā cell."

Mitochondrial dysfunction

Ua kuhi mua ʻia ʻo Mitochondrial dysfunction ma ke ʻano he wehewehe hiki ke wehewehe i kekahi o nā hōʻailona lōʻihi o ka coronavirus, akā ke waiho mau nei kahi mea pohihihi e pili ana i ke ʻano o ka maʻi SARS-CoV-2 i kumu i ka mitochondrial dysfunction. ʻOiai ua manaʻo mau ʻia ka hoʻomaʻamaʻa ʻana he mea pono no ka hana mitochondrial, ʻaʻole pili ke kānāwai i nā maʻi maʻi [long Covid], wahi a Foust. ʻIke loa, hiki ke hōʻemi i ka hana mitochondrial a me ka hopena o ka infiltration cell immune

Hooikaika kino mama

Ua ʻōlelo ʻo Brent Appleman, kahi mea noiʻi ma ka noiʻi ʻo Amsterdam, e makaʻala nā mea maʻi Covid lōʻihi ʻaʻole e hoʻoikaika iā lākou iho ma mua o ko lākou palena. I kēia manawa ua ʻike maopopo ʻia ʻo ka hoʻoikaika nui ʻana he mea pōʻino, a ʻike maopopo ʻia ke kumu.

"ʻOiaʻiʻo, hiki ke ʻōlelo ʻia kēia mau mea maʻi [hoʻihoʻi mai Covid lōʻihi) e mālama i ko lākou mau palena kino a ʻaʻole i ʻoi aku ma mua o lākou, no ka mea hiki iā lākou ke hana maʻalahi i ka hoʻopiʻi ʻole ʻana i nā hoʻopiʻi," wahi a Appleman. kaʻa kaʻa uila no ka hoʻomaikaʻi ʻana i ke kūlana.

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