Hiki ke loaʻa iā Alzheimer ma mua o ka maʻi?

Hiki ke loaʻa iā Alzheimer ma mua o ka maʻi?

Ke ʻimi nei i kahi ala palekana a maikaʻi hoʻi e wānana i ka maʻi o Alzheimer, ua ʻike nā mea noiʻi Suedena i kahi mole kō i loko o ke koko o nā maʻi i hoʻopilikia ʻia.

I ka hui ʻana i kahi hoʻāʻo hoʻomanaʻo maʻalahi me ka loiloi genetic, hiki i ka hui noiʻi ke wānana i ka hoʻomaka ʻana o ke kūlana he ʻumi makahiki ma mua me kahi kiʻekiʻe o ka pololei.

ʻOiai ʻo ka protocol hou i ʻike ʻia e hiki ke hui pū me nā protocol diagnostic mua no Alzheimer e kōkua koke i nā ʻepekema e ʻike i ka hiki ke loaʻa i ka maʻi ma mua o ka hoʻomaka ʻana o kāna mau hōʻailona a hana i nā hana e hoʻōki i kona holomua.

ʻO nā ala maʻalahi

Kokoke i kēlā me kēia lā, ʻike ʻia nā kānaka ʻepekema e hoʻokokoke a kokoke i ka ʻimi ʻana i nā ala hou e wānana i ka hoʻomaka ʻana o ka maʻi o Alzheimer, e like me New Atlas, e haʻi ana i ka puke pai Alzheimer's & Dementia. ʻO ka hoʻāʻo ʻana e hoʻohana i nā mea hiki ke hoʻohana ʻia e nānā i nā ʻōnaehana neʻe e pili ana i ke kūlana a hoʻohana i nā algorithms e hiki ke kālailai i ka positron emission tomography scans e ʻike i nā hōʻailona o ka maʻi ma mua i hōʻike ʻia ma mua, a me nā loiloi i loaʻa he 75 mau wahi genomic pili i ka maʻi. .

Hiki i ka hoʻāʻo ʻana i nā wai kino ke hāʻawi i nā hopena hoʻohiki e like me ke ʻano wānana. Akā no ka mea ʻo ka wehe ʻana i ka wai cerebrospinal he manaʻo paʻakikī, ʻo nā mea noiʻi, me ka poʻe ma Karolinska Institutet ma Sweden, ke hoʻāʻo nei e ʻimi i nā ala e ʻike ai i ka maʻi me ka hoʻohana ʻana i nā hoʻokolohua koko maʻalahi.

Tau proteins

Ma mua, ua ʻike nā mea noiʻi ʻo nā mea i hoʻokumu ʻia i ke kō, i kapa ʻia ʻo glycans i loaʻa i ka wai cerebrospinal, hiki ke hoʻopaʻa i ke alo o nā protein tau i ke kino. ʻO nā pae kiʻekiʻe o ka protein tau abnormal i loko o ka lolo kekahi o nā hōʻailona mua o ka maʻi o Alzheimer, no laila ʻo ka loaʻa ʻana i ka wā mua o ke kino he ala ia e wānana ai i ka hoʻomaka ʻana o ke ʻano.

ʻO ka ʻoiaʻiʻo, ua ʻike ka hui ʻelua o ka poʻe me nā pae like o ka glycans a me ka tau e hoʻomohala i ka maʻi Alzheimer ma mua o ka poʻe ʻaʻohe hōʻailona.

ʻO Glycans i loko o ke koko

I loko o ka noiʻi hou, ua ʻike nā mea noiʻi ʻo nā glycans, ʻo ia hoʻi nā sugars koko a i ʻole nā ​​molekele pili koko e uhi ana i nā protein, aia pū kekahi i loko o ke koko.

Ma ka hoʻohui ʻana i kēia ʻike me ka loiloi genetic a me ka hoʻāʻo hoʻomanaʻo, ua hiki iā lākou ke wānana i ka hoʻomaka ʻana o ka maʻi o Alzheimer me 80% pololei a hiki i 10 mau makahiki ma mua o ka ʻike ʻana o nā hōʻailona o ka nalowale hoʻomanaʻo.

He kahua ʻike ʻole ʻia

No kāna ʻāpana, ʻo ka mea noiʻi mua o ka noiʻi, ʻo Robin Zhu, mai ka Karolinska Institutet, i ʻōlelo ʻia: "ʻO ka hana o nā glycans, nā hale i hana ʻia i nā molekole kō, he wahi i ʻike ʻole ʻia i ka noiʻi dementia. "Ua hōʻike ʻia nā hopena o ke aʻo ʻana e loli ke kiʻekiʻe o ke koko o ka glycans i ka wā o ka ulu ʻana o ka maʻi, ʻo ia ka mea hiki ke wānana ʻia ka pilikia o ka hoʻomohala ʻana i ka maʻi o Alzheimer mai kahi hoʻāʻo koko a me ka hoʻomanaʻo hoʻomanaʻo wale nō."

Ma ke ʻano he hana aʻe, e aʻo nā mea noiʻi i nā laʻana koko hou i hoʻokomo ʻia i loko o ka noiʻi Swedish a me nā haʻawina kahiko i hana ʻia ma waho o ka ʻāina. E hana pū ka pūʻulu noiʻi e hoʻokō i nā ʻike i ka hoʻomaʻamaʻa ma nā hoʻonohonoho lapaʻau.

ʻO ka mea noiʻi alakaʻi o ka noiʻi ʻo Shedden Weiss, ua hōʻike pū i kona manaʻolana "ʻo nā glycans i loaʻa i loko o ke koko e hōʻoia i ka waiwai nui i nā ʻano o ka nānā ʻana i ka poʻe no Alzheimer, kahi e hiki ai ke ʻike mua i ka maʻi."

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