Kuchita masewera olimbitsa thupi kungapangitse kuopsa kwa thanzi

Kuchita masewera olimbitsa thupi kungapangitse kuopsa kwa thanzi

Chimodzi mwazizindikiro zodziwika bwino za COVID-19 kwanthawi yayitali ndi chizolowezi chochita masewera olimbitsa thupi, zomwe zimakulitsa vutoli.

Kutha kwa nthawi yayitali kwa kachilombo ka Corona sikungochepetsa mphamvu ya munthu yochita masewera olimbitsa thupi, koma zizindikiro zambiri zimawonekera patatha masiku ophunzirira, ndipo ochita kafukufuku atcha izi "post-exertional malaise" (PEM), zomwe ndi chodabwitsa kwambiri.

Kufotokozera zathupi ndi maziko

Malingana ndi zomwe zinasindikizidwa ndi webusaiti ya New Atlas, kutchula maphunziro awiri omwe zotsatira zake zinasindikizidwa m'magazini ERJ Open Research ndi Nature Communications, nthawi zambiri zolimbitsa thupi, kuchita masewera olimbitsa thupi kumakhala kopindulitsa, ndipo pamene wodwala akuvutika ndi masewera olimbitsa thupi, nthawi zambiri pamakhala zomveka bwino za thupi. Mafotokozedwe, monga Mtima kapena mapapo sakugwira ntchito bwino, kapena nthawi yayitali ya kudwala ikhoza kupangitsa kuti thupi likhale lofooka pomwe thupi limafooka.

Koma nthawi zambiri za COVID-19 yanthawi yayitali, palibe zizindikilo zomveka bwino zomwe zimafotokoza zoletsa kuchita masewera olimbitsa thupi. kudwala kwa nthawi yayitali Ndi Corona virus.

Ngakhale zotsatira zake sizimaloza mayankho mwachangu, zikutsimikizira kuti milandu yochita masewera olimbitsa thupi kwanthawi yayitali yokhudzana ndi kachilombo ka Corona imakhala ndi maziko amthupi.

Cardiopulmonary exercise test

Mayeso achikhalidwe kwambiri a momwe wodwalayo amagwirira ntchito amatchedwa "cardiopulmonary exercise test" (CPET). Wodwalayo amaikidwa panjinga yochita masewera olimbitsa thupi pamene madokotala amayang'anitsitsa kuthamanga kwa mtima, kuchuluka kwa oxygen, ndi electrocardiogram data.

Kwa odwala ambiri a coronavirus a nthawi yayitali, kufufuza kwa CPET kumabweretsa zotsatira zachilendo. Ngakhale kuti pali zolepheretsa zoonekeratu kuchita masewera olimbitsa thupi monga kupuma movutikira, odwalawa nthawi zambiri amawonetsa mpweya wabwino wa okosijeni ndi ntchito yabwino ya mtima.

Zochita zolimbitsa thupi za cardiopulmonary

Gulu la ofufuza ku yunivesite ya Yale lidachita kafukufuku pa gulu la odwala omwe atenga nthawi yayitali omwe amaphatikiza mayeso atsopano a CPET, omwe amadziwika kuti iCPET kapena kuyesa kolimbitsa thupi kwa mtima, komwe kumakhala kovuta kwambiri kuposa kuyesa kwanthawi zonse kwa CPET. Kuphatikiza pa njira zokhazikika za CPET, ma catheter awiri othamanga amalowetsedwa m'mitsempha ya odwala omwe akuyesedwa, kulola kuyang'ana kowonjezera pa zotsatira za masewera olimbitsa thupi pa minofu ndi mitsempha ya magazi.

Dongosolo la oxygen m'zigawo

Zotsatira zake zinali zodabwitsa, ndipo zinasonyeza kuti palibe vuto lililonse la mmene mtima kapena mapapu amagwirira ntchito, koma zinasonyeza kuti pali vuto linalake la mmene minyewa ya m’thupi imatengera mpweya wa okosijeni. Kulephera kugwira ntchito kunayesedwa ngati kusokonezeka kwadongosolo kwa oxygen pEO2.

Peter Kahn, wofufuza wamkulu pa phunziroli, anafotokoza kuti anapeza kuti "ngakhale kuti mtima unali kupopa magazi okosijeni operekedwa ndi mapapo ndi mpweya wokwanira wa okosijeni, kuchotsa kwa okosijeni m'matenda a thupi kunasokonezedwa ndi odwala omwe amasonyeza zizindikiro. za kusalolera masewera olimbitsa thupi. ” Masewera pambuyo pa Covid. " Koma sizikanatheka kuganiziridwa ndendende chifukwa chake kapena momwe izi zidachitikira, monga ochita kafukufuku adawonetsa mafotokozedwe angapo otheka a chodabwitsa ichi.

Ofufuza a kafukufukuyu amalingalira kuti "kuwonongeka kwa pEO2 kungakhale chifukwa cha kulephera kwa mabedi osachita masewera olimbitsa thupi kuti atseke vasoconstriction mokwanira kapena kuthamanga kwa magazi mwachindunji, kapena kusakwanira kwa capillary kufalikira kwa mitochondria."

Umboni wochititsa chidwi

Kafukufuku, wofalitsidwa posachedwapa m’magazini yotchedwa Nature Communications, yochitidwa ndi gulu la asayansi pa yunivesite ya Amsterdam, ikupereka mfundo zosangalatsa zimene zingachitike. Yankho likuwoneka kuti likugwirizana ndi mitochondria, timitengo tating'onoting'ono tamphamvu tomwe timapatsa mphamvu ma cell.
Mayesero apadera kwambiri a University of Amsterdam adaphatikizapo gulu la odwala a coronavirus anthawi yayitali komanso gulu lowongolera athanzi. Ophunzirawo adamaliza kuyesa kwapanjinga movutikira, kupereka zitsanzo zamagazi ndi minofu sabata imodzi isanachitike komanso tsiku limodzi pambuyo pa mayeso.

Zolakwika mu minofu ya minofu

Rob West, wofufuza yemwe adachita nawo kafukufukuyu, adati kuchepa kwa metabolic komanso zisonyezo za kuwonongeka kwakukulu kwa minofu zidapezeka mwa odwala a Covid kwa nthawi yayitali atachita masewera olimbitsa thupi. Mwinanso chofunikira kwambiri, zotsatira zake zidawululira kuti kuchita masewera olimbitsa thupi molimbika kumayambitsa kusagwira bwino ntchito kwa mitochondrial m'maselo a minofu, zomwe zitha kufotokozera chifukwa chomwe odwala omwe ali ndi Covid yayitali amamva kuipiraipira tsiku lotsatira kulimbitsa thupi.

"Tidawona zolakwika zosiyanasiyana m'minofu ya odwala," akufotokoza Foust. "Pamlingo wa ma cell, tidawona kuti mitochondria ya minofu, yomwe imadziwikanso kuti mafakitale amagetsi a cell, imagwira ntchito mochepera komanso imatulutsa mphamvu zochepa kuchokera m'maselo."

Kulephera kwa Mitochondrial

Kusagwira ntchito kwa mitochondrial m'mbuyomu kunkaganiziridwa kuti ndi njira yofotokozera zina mwazomwe zimayambitsa matenda a coronavirus, koma padakali chinsinsi kuti matenda a SARS-CoV-2 amayambitsa bwanji kusagwira bwino ntchito kwa mitochondrial. Ngakhale kuchita masewera olimbitsa thupi nthawi zonse kumawonedwa ngati kopindulitsa pakugwira ntchito kwa mitochondrial, lamuloli siligwira ntchito kwa odwala [atali a Covid], Foust adanena. Mwachiwonekere, kuwonongeka kwa minofu ndi kulowetsedwa kwa maselo a chitetezo cha mthupi kungachepetsenso ntchito ya mitochondrial

Zovuta zolimbitsa thupi

Brent Appleman, wochita nawo kafukufuku ku Amsterdam, akuti odwala a Covid anthawi yayitali akuyenera kusamala kuti asamayesetse kupitilira malire awo. Tsopano zikuwonekeratu kuti kulimbikira kwambiri kumakhala kovulaza, ndipo chifukwa chake ndikumveka bwino.

"Zowonadi, odwalawa [akuchira ku Covid) amatha kulangizidwa kuti asunge malire awo osapitilira, chifukwa amatha kuchita khama zomwe sizikuwonjezera madandaulo," akutero Appleman, pozindikira kuti "kuyenda ndikwabwino kapena kukwera njinga yamagetsi kuti akonze vutolo.” “Thanzi ndi kukhala ndi thanzi labwino, ndipo munthu aliyense ayenera kukumbukira kuti zimene zimagwirizana ndi ena zingakhale zotopetsa kwa iye.”

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