Chenjerani..mankhwala ochiza khansa, amayambitsa khansa

Kafukufuku amene anachitika ku United States anasonyeza kuti kusokonezeka kwa majini kwa amuna ena amene ali ndi kansa ya prostate kungasokoneze mmene angachitire ndi mankhwala amene amagwiritsidwa ntchito pochiza matendawa. Ofufuza omwe adachita nawo kafukufukuyu, yemwe adasindikizidwa posachedwa m'magazini ya Clinical Investigation, akukhulupirira kuti zotsatira zawo zitha kupereka chidziwitso chofunikira pozindikira odwala omwe atha kukhala bwino akalandira chithandizo ndi mankhwala ena.

Ofufuza apeza kuti abiraterone, mankhwala odziwika a khansa ya prostate, amatulutsa milingo yambiri ya testosterone ngati yopangidwa ndi amuna omwe ali ndi matenda apamwamba omwe ali ndi kusintha kwina kwa chibadwa.

Dr. Nima Sharifi, MD, wa Lerner Research Institute of Cleveland Clinic, adapeza kale kuti amuna omwe ali ndi khansa ya prostate yaukali omwe anali ndi kusintha kwapadera mu jini ya HSD3B1 ali ndi zotsatira zochepa kwambiri za mankhwala kusiyana ndi odwala omwe alibe. Jini la HSD3B1 limayika enzyme yomwe imalola ma cell a khansa kudyetsa ma adrenal androgens. Enzyme iyi imakhala yochuluka kwambiri kwa odwala omwe ali ndi kusintha kwa jini ya HSD3B1 (1245C).

Dr. Sharifi ndi gulu lake mu Dipatimenti ya Biology ya Cancer Biology, kuphatikizapo wolemba woyamba wa phunziroli, wofufuza Dr. Muhammad Al Yamani, adapeza kuti amuna omwe ali ndi vuto lachibadwa la chibadwa amagwiritsira ntchito abiraterone mosiyana ndi anzawo popanda kusintha kwa majini.

Dr. Sharifi ananena kuti ali ndi chiyembekezo chakuti zotsatirazi zitithandiza “kukulitsa luso lathu lochiza khansa ya prostate potengera mmene chibadwa cha gulu lililonse la odwala chilili.” Iye anati, “Maphunziro owonjezereka akufunika, koma tili ndi umboni wamphamvu wakuti mmene wodwalayo alili. jini ya HSD3B1 imakhudza chitetezo cha m’thupi.” Kagayidwe kake ka Abiraterone, ndipo mwinamwake kugwira ntchito kwake, ndipo ngati zimenezi zatsimikiziridwa, tikuyembekeza kuti tidzatha kuzindikira mankhwala ena othandiza amene angakhale ogwira mtima kwambiri mwa amuna amene ali ndi vuto la majini limeneli.”

Chithandizo chachikhalidwe cha khansa ya prostate yapamwamba, yotchedwa "androgen deprivation therapy," imalepheretsa kupezeka kwa ma androgens kumaselo omwe amawadyetsa ndikuwagwiritsa ntchito kukula ndi kufalikira. Ngakhale kuti njira yochizira imeneyi inathandiza kwambiri matendawa atangoyamba kumene, maselo a khansa amayamba kusonyeza kukana njira imeneyi, zomwe zimachititsa kuti matendawa athe kufika pamlingo wakupha wotchedwa “castration-resistant prostate cancer,” pamene maselo a khansa amayamba gwero lina la androgens, adrenal glands. Abiraterone imaletsa ma adrenal androgens kuchokera ku maselo a khansa.

Mu phunziro ili, ochita kafukufuku adafufuza zowonongeka za ma molekyulu a abiraterone m'magulu angapo a amuna omwe adapita patsogolo mpaka kumtunda wosagonjetsedwa, ndipo adapeza kuti odwala omwe ali ndi kusintha kwa majini anali ndi metabolite yambiri yotchedwa 5α-abiraterone. Metabolite iyi imanyenga cholandilira cha androgen polimbikitsa njira zakukula zomwe ndizowopsa ku khansa. Chodabwitsa n'chakuti, mankhwalawa a abiraterone metabolism, omwe poyamba adapangidwa kuti aletse androgens, akhoza kuchita ngati androgens ndikuyambitsa kukula kwa maselo a khansa ya prostate. Kufufuza momwe abiraterone imakhudzira zotsatira zachipatala kwa odwala khansa ya prostate yosagonjetsedwa ndi castration idzakhala sitepe yotsatira yofunikira.

Dr. Eric Klein, pulezidenti wa Glickman Urological and Kidney Institute ku Cleveland Clinic, adanena kuti kafukufukuyu "amapititsa patsogolo kumvetsetsa za kusokonezeka kwa kusintha kwa majini mu jini ya HSD3B1, ndipo akulengeza njira yolimba yachipatala yochizira amuna omwe ali ndi khansa ya prostate. ."

Kafukufukuyu adathandizidwa mwa zina ndi thandizo la National Cancer Institute la US Department of Health and Human Services ndi Prostate Cancer Foundation. Dr. Howard Sully, wachiwiri kwa pulezidenti wamkulu komanso mkulu wa sayansi ya bungwe lopanda phindu, adalongosola kuti kafukufukuyu akuthandiza kuzindikira "njira yatsopano yokana" ku mankhwala abiraterone omwe amagwiritsidwa ntchito pochiza odwala khansa ya prostate, ndi Kuyamikira ndi kunyada kwa Prostate Cancer Foundation kwa Dr. "Tikukhulupirira kuti zomwe Dr. Sharifi ndi gulu lake apeza zithandiza posankha njira zosiyanasiyana zothandizira odwala omwe ali ndi kusintha kwa majini mu jini ya HSD3B1, kuti apitirize kuyankhidwa kwachipatala, ” adatero.

Dr. Sharifi ali ndi Kendrick Family Chair mu Prostate Cancer Research ku Cleveland Clinic ndipo amatsogolera Cleveland Clinic Center of Excellence mu Prostate Cancer Research, ndipo amakumana ndi Glickman Urology ndi Impso Institute ndi Taussig Cancer Institute. Mu 2017, Dr. Sharifi adapatsidwa mphoto ya "Top Ten Clinical Achievements" kuchokera ku Clinical Research Forum chifukwa cha zomwe adazipeza kale za jini ya HSD3B1.