Chithandizo cha odwala mphumu chomwe chimachepetsa zotsatira zake zoyipa

Chithandizo cha odwala mphumu chomwe chimachepetsa zotsatira zake zoyipa

Kugwiritsa ntchito biologic therapy kuchepetsa kutupa m'mapapo kunathandiza 92% ya anthu omwe ali ndi mphumu yoopsa kuti achepetse mlingo wawo watsiku ndi tsiku wa ma steroids osawonjezera zizindikiro zawo, kafukufuku watsopano wapeza. Zomwe anapezazi zikutanthawuza kuti anthu omwe ali ndi mphumu yoopsa akhoza kuchepetsa chiopsezo cha zotsatira zoipa zomwe zimagwirizanitsidwa ndi kugwiritsa ntchito steroid kwa nthawi yaitali, malinga ndi New Atlas, potchula The Lancet.

Mwa anthu pafupifupi 300 miliyoni omwe ali ndi mphumu padziko lapansi, pafupifupi 3% mpaka 5% ali ndi mphumu yowopsa, kupuma movutikira tsiku ndi tsiku, chifuwa cholimba komanso chifuwa chomwe nthawi zambiri chimatsogolera ku chipatala. Anthu odwala mphumu yoopsa kwambiri amakhala ndi mtundu wina wotchedwa eosinophilic asthma, womwe umadziwika ndi kuchuluka kwa maselo a chitetezo chamthupi (eosinophils) m'magazi omwe amayambitsa kutupa kosalamulirika komanso kutupa kwa mpweya.

Pewani mavuto omwe angakhalepo

Mankhwala ovomerezeka a mphumu ya eosinophilic, malinga ndi Global Initiative for Asthma (GINA), ndi kuphatikiza kwa tsiku ndi tsiku kwa budesonide (inhaled corticosteroid kuti athetse kutupa) ndi formoterol (bronchodilator yomwe imakhala nthawi yaitali kuti ipumule ndi kutsegula mpweya). Mankhwalawa, omwe amadziwika kuti ICS kapena "steroid," amakondedwa kusiyana ndi "rescue" inhalers yaifupi chifukwa cha zotsatira zake ziwiri zotsutsana ndi kutupa ndi bronchodilator. Koma kugwiritsidwa ntchito kwa nthawi yaitali kungakhale kovuta, chifukwa kumayenderana ndi thrush m'kamwa, osteoporosis, shuga, kufooka kwa chitetezo cha mthupi, ndi ng'ala.

Kafukufuku, wochitidwa ndi asayansi ochokera ku King's College London pa odwala m'maiko anayi: United Kingdom, France, Italy ndi Germany, adafufuza ngati chithandizo cha benralizumab (mankhwala achilengedwe) chimalola anthu omwe ali ndi mphumu yayikulu ya eosinophilic kuchepetsa mlingo wa ICS popanda kutaya. kuchepetsa zizindikiro zawo.

David Jackson, mtsogoleri wa gulu lofufuza, adati: "Machiritso achilengedwe monga benralizumab asintha chisamaliro chachikulu cha mphumu m'njira zambiri, ndipo zotsatira za kafukufuku watsopano zikuwonetsa kwa nthawi yoyamba kuti kuvulala kokhudzana ndi ma steroid kumatha kupewedwa ambiri odwala amene amagwiritsa ntchito mankhwalawa.”

Benralizumab amaperekedwa ndi jakisoni wa subcutaneous kamodzi pa milungu inayi iliyonse pamilingo itatu yoyambirira, kenako kamodzi pa milungu isanu ndi itatu iliyonse.

Zotsatira za kafukufukuyu zidawonetsa kuti, ambiri, 92% ya omwe adatenga nawo gawo adachepetsa mlingo wa ICS. Mwachindunji, 15% ya iwo adachepetsa mlingo mpaka mlingo wapakati, 17% mpaka mlingo wochepa, ndi 61% pa mlingo wofunikira kokha. Komanso, 91% ya omwe adatenga nawo mbali sanakumane ndi kuwonjezereka kwazizindikiro panthawi yojambula.

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