Ma sutures opangira opaleshoni omwe amafulumizitsa kuchira pambuyo pa opaleshoni

Ma sutures opangira opaleshoni omwe amafulumizitsa kuchira pambuyo pa opaleshoni

Ofufuza ku Massachusetts Institute of Technology apanga ma sutures osungunuka omwe amatha kudzazidwa ndi masensa a ma cell kapena mankhwala ngati pakufunika.

Zatsopanozi zikufuna kufulumizitsa kuchira pambuyo pa maopaleshoni kapena kuzindikira kutayikira kulikonse kapena zolakwika pamalo opangira opaleshoni, malinga ndi zomwe zidasindikizidwa ndi New Atlas, kutchula magazini ya Matter.

Greece wakale

Malinga ndi kunena kwa dokotala wa opaleshoni Wachigiriki, Galen wa ku Pergamoni ku Girisi wakale, pamene oseŵera omenyana anavulala msana, asing’anga ankagwiritsa ntchito ulusi wopangidwa ndi silika ndi matumbo a nkhosa kapena akavalo pofuna kuchiza chovulalacho. Opaleshoni ya sutures ndi ulusi, zomwe zinapangidwa kuchokera m'matumbo a nyama, zimatchedwa "Cat Guts", ngakhale kuti zina sizikugwirizana ndi ziwalo zamkati za zinyama.

Matumbo amphaka kapena ng'ombe

Dzinali limatanthauza matumbo amphaka kapena magulu a ng'ombe, kutanthauza "cat gut" poyerekezera ndi amphaka mu Chingerezi, kapena ng'ombe mwachidule ng'ombe. Mawonekedwe a sutures amagwiritsidwabe ntchito masiku ano m'ma opaleshoni ena, makamaka pamene sutures sangathe kuchotsedwa mosavuta, chifukwa sutures amasungunuka mwachibadwa m'masiku 90.

Ma biomolecules ndi ma hydrogel

Poyesa kukulitsa kugwiritsa ntchito ma sutures osungunuka ndi bio, ofufuza a MIT adatenga minofu ya nkhumba ndikugwiritsa ntchito njira yotsukira kuti atsuke ndikuchotsa ma cell, kuti apeze ulusi wopangidwa makamaka ndi collagen ndi ma biomolecules ena. Ulusiwo, womwe adautcha kuti De-gut, udayikidwa mu hydrogel asanaphatikizidwe mu mamolekyu osiyanasiyana mu gel kuti athandizire kuchira ndi kumva.

gel polish

"Suture" yopangidwa ndi biodegradable [opaleshoni] yosinthidwa ndi hydrogel wosanjikiza imatha kukhala nkhokwe yosungiramo zotupa zotupa, kapena mankhwala monga ma antibodies a monoclonal kuti athetse kutupa," adatero, ndikuwonjezera kuti "ndizodabwitsa kuti [ma sutures atsopano] alinso ndi mphamvu yosunga ma cell amoyo kwa nthawi yayitali. ”

kuzindikira matenda

Pa kafukufuku wa sensa, Traverso ndi gulu lake lofufuza adayika ma microparticles okhala ndi peptide mu hydrogel. Ma peptides amatulutsidwa pamene ma enzyme okhudzana ndi kutupa analipo. Akatulutsidwa, ma peptides amatha kudziwika mumkodzo, kotero kuti kukodza kosavuta kungathe kuwapeza ndikudziwitsa madokotala za kukhalapo kwa matenda pamalo a suture mkati mwa thupi.

Pamutu kulowetsedwa wa mankhwala

Popereka mankhwala, ofufuzawo adaphatikizira bwino zida zomwe zimagwiritsidwa ntchito pochiza matenda otupa m'matumbo mu hydrogel. Ma antibodies onse a monoclonal ndi ma steroid adayikidwa mu ma polima omwe amagwiritsidwa ntchito kuwongolera kuchuluka kwa mankhwala, omwe kenako amanyamulidwa mu hydrogel pamwamba pa ulusi. Ofufuzawo akuti mankhwala ena amathanso kuphatikizidwa, kuphatikiza maantibayotiki kapena mankhwala a chemotherapy.

Kutumiza kwa stem cell

Ofufuzawo adagwiritsa ntchito ma sutures kuti apereke ma cell tsinde, omwe adapangidwa kuti aziwonetsa zolembera za fulorosenti, ndipo potsata ma cell owala, adapeza kuti amakhalabe otheka pamwamba pa ma sutures mkati mwa matupi a mbewa za labu kwa masiku osachepera asanu ndi awiri. Maselo a tsinde adathanso kupanga chinthu chotchedwa vascular endothelial growth factor (VEGF), chomwe chimapangitsa kupanga maselo atsopano a magazi omwe angathandize kuchira msanga pamalo opangira opaleshoni mkati mwa thupi.

Kudzoza

Gulu lofufuza poyamba linalimbikitsidwa ndi lingalirolo pambuyo popeza ma sutures omwe angagwire ntchito bwino kwa odwala omwe ali ndi matenda a Crohn, matenda otupa omwe ali ovuta kwambiri angayambitse kuchotsedwa kwa ziwalo za matumbo a odwala. Ofufuzawo akuyembekeza kuti zotsatira za phunziroli zidzatsogolera kugwiritsa ntchito ma sutures atsopano mu njira zosiyanasiyana za opaleshoni.

Maulosi a horoscope a Maguy Farah a chaka cha 2023