Kudzidzira muviri kunogona kuwedzera kuoma kwehutano hwehutano

Kudzidzira muviri kunogona kuwedzera kuoma kwehutano hwehutano

Chimwe chezviratidzo zvinowanzoitika zvenguva refu yeCCIDID-19 itsika yekuita kurovedza muviri kwakanyanya, izvo zvinowedzera mamiriro acho.

Mhedzisiro yenguva refu yehutachiona hweCorona haingogumiri pakuderedza kugona kwemunhu kurovedza muviri, asi zviratidzo zvakakura zvinowanzoitika mumazuva anotevera zvidzidzo zvekudzidziswa, uye vaongorori vakadana chiitiko ichi "post-exertional malaise" (PEM), iyo chinhu chinoshamisa.

Physiological tsananguro uye nheyo

Maererano nezvakabudiswa neNew Atlas website, ichitaura zvidzidzo zviviri zvakabuda mumagazini ERJ Open Research uye Nature Communications, mumatambudziko akawanda ekugadzirisa, kurovedza muviri kunobatsira, uye kana murwere achitambura nekurovedza muviri, kazhinji pane zvakajeka zvemuviri. tsananguro, seMwoyo kana mapapu anogona kunge asiri kushanda zvakanaka, kana nguva yakareba yehurwere inogona kunge yakatungamira kune rudzi rwekubvisa muviri uko muviri unowanzo kushaya simba.

Asi muzviitiko zvakawanda zvenguva refu yeCCIDID-19, hapana zviratidzo zvakajeka zvinotsanangura zvirambidzo zvekurovedza muviri.Varwere vazhinji vakabhombwa nemiedzo yechinyakare kungoudzwa kuti vakanyatsonaka, asi zvidzidzo zvitsva zvakati wandei zviri kutanga kuburitsa chakavanzika kuseri. Kurwara kwenguva refu.NeCorona virus.

Kunyangwe mhedzisiro yacho isingabve yanongedza mhinduro, vanosimbisa kuti nyaya dzekugara kwenguva refu kusashivirira dzine chekuita nehutachiona hweCorona dzine hwaro hwemuviri.

Cardiopulmonary exercise test

Muedzo wechinyakare wekugona kushanda kwemurwere unonzi cardiopulmonary exercise test (CPET). Murwere anoiswa pabhasikoro rekurovedza muviri apo vanachiremba vachitarisa kurova kwemwoyo, kuzara kweokisijeni, uye data ye electrocardiogram.

Kune vazhinji varwere venguva refu yekoronavirus, kuferefetwa kweCPET kunodzosera zvakajairika mhedzisiro. Pasinei nekukanganisa kuri pachena kwekuita senge kupfupika kwekufema, varwere ava vanowanzoratidza mazinga eokisijeni akajairwa uye kushanda kwemoyo une hutano.

Invasive cardiopulmonary exercise

Chikwata chevaongorori paYale University vakaita ongororo paboka revarwere venguva refu yekoronavirus iyo yaisanganisira mutsva weCPET muyedzo, unozivikanwa seICPET kana invasive cardiopulmonary exercise test, iyo yakaoma kupfuura yenguva dzose CPET bvunzo. Mukuwedzera kune maitiro eCPET nguva dzose, makateta maviri ekudzvinyirira anopinzwa mutsinga dzevarwere vari kuedzwa uku, zvichibvumira kutarisa kwekuwedzera pamigumisiro yekurovedza muviri pamisungo neropa.

Systemic kubviswa kweokisijeni

Migumisiro yacho yaishamisa, yaisaratidza matambudziko aioneka mumashandiro anoita mwoyo kana mapapu, asi yakaratidza kusakwana kuri pachena munzira iyo matishu emuviri anotora oxygen. Dysfunction yakarongerwa sekukanganiswa systemic oxygen kutorwa pEO2.

Peter Kahn, muongorori mukuru wechidzidzo ichi, akatsanangura kuti zvakaonekwa kuti "zvisinei nekuti moyo waipomba ropa reokisijeni rinopihwa nemapapu rine huwandu hwakakwana hweokisijeni, kubviswa kweokisijeni kubva mumiviri yemuviri kwakakanganiswa muvarwere vairatidza zviratidzo. yekusashivirira muviri." Mitambo mushure meCovid." Asi hazvaigona kufungidzirwa kuti sei chaizvo kana kuti sei izvi zvakaitika, sezvo vaongorori vakanongedzera kune akati wandei angangove tsananguro yeichi chiitiko chisina kujairika.

Vatsvakurudzi vekudzidza vanofungidzira kuti "kukanganiswa kweEO2 kunogona kukonzerwa nekukundikana kwevasina-exercise vascular beds kuti vanyatsogadzirisa vasoconstriction kana kutenderera kweropa remisumbu, kana kusakwana kwecapillary diffusion kune mitochondria."

Uchapupu hunonakidza

Ongororo, ichangobva kuburitswa mumagazini yeNature Communications, yakaitwa nechikwata chemasayendisiti paYunivhesiti yeAmsterdam, inopa mazano anonakidza nezvezvingave zvichiitika. Mhinduro inoita kunge ine chekuita nemitochondria, diki diki remagetsi rinopa simba masero ega.
Muedzo weYunivhesiti yeAmsterdam wakasarudzika waisanganisira boka revarwere venguva refu yekoronavirus uye boka rekutonga rine hutano. Vatori vechikamu chekudzidza vakapedza bvunzo yakasimba yebhasikoro, vachipa masampu eropa uye tsandanyama svondo risati rasvika uye rimwe zuva mushure mekuyedzwa.

Abnormalities mune tsandanyama tishu

Rob West, muongorori akabatanidzwa muchidzidzo ichi, akati kushomeka kwemasabolism uye zviratidzo zvekukuvara kwakakura kwemhasuru zvakawanikwa muvarwere veCovid kwenguva yakareba mushure mekuita maekisesaizi. Zvichida zvakanyanya kukosha, mhedzisiro yakaratidza kuti kurovedza muviri kwakasimba kwakakonzera kusagadzikana kwemitochondrial mumaseru mhasuru, izvo zvinogona kutsanangura kuti nei varwere veCovid-refu vachinzwa zvakanyanya zuva rakatevera kurovedza muviri.

"Takaona kusakwana kwakasiyana munyama yevarwere," Foust anotsanangura. "Padanho remasero, takaona kuti tsandanyama mitochondria, inozivikanwawo semafekitari emagetsi esero, inoshanda zvishoma uye inogadzira simba shoma kubva kumaseru."

Mitochondrial dysfunction

Mitochondrial dysfunction yakambofungidzirwa setsananguro inogona kuitika kune zvimwe zvezviratidzo zvenguva refu zvekoronavirus, asi pachine chakavanzika chekuti sei hutachiona hweSARS-CoV-2 hunokonzera kusashanda zvakanaka kwemitochondrial. Kunyangwe maekisesaizi achigara achionekwa seanobatsira pakuita mitochondrial, mutemo haushande kune [yakareba Covid] varwere, Foust akadaro. Zviripachena, kukuvadzwa kwemhasuru uye kukonzeresa kupinza masero emuviri kunogona kuderedza mitochondrial basa zvakare

Kuedza muviri kwakareruka

Brent Appleman, mumwe muongorori muAmsterdam kudzidza, anoti varwere venguva refu veCovid vanofanirwa kungwarira kuti vasashande nesimba kupfuura zvavari kufanira. Iye zvino zviri kuwedzera kujeka kuti kuedza zvakanyanya kunokuvadza, uye chikonzero chacho chinonyatsonzwisiswa.

"Chaizvoizvo, varwere ava [vanopora kubva kuCovid-yakareba] vanogona kurairwa kuti vachengetedze miganhu yavo uye kuti varege kuipfuura, sezvo vachigona kuita basa rakareruka risingawedzere zvichemo," Appleman anodaro, achiona kuti "kufamba kwakanaka kana kuchovha bhasikoro remagetsi kuti uvandudze mugariro wacho.” “Utano nokuchengeta muviri wakagwinya, uye munhu ari wose anofanira kurangarira kuti icho chinokodzera vamwe chingava chinomunetesa.”

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