Munhu anotapukirwa sei neCOVID-19?

Munhu anotapukirwa sei neCOVID-19?

Sezvo zvidzidzo zvichiramba zvichiburitsa maitiro ehutachiona hweCorona, hwanetsa pasirese kweanoda kusvika makore maviri, masayendisiti epaYunivhesiti yeGlasgow Center yeVirus Research muScotland akawona gene rinokanganisa kuomarara kunoita munhu kushivirira hutachiona hweCovid-19. .

Panguva imwecheteyo, vaongorori vane chidzidzo chakabudiswa mujenari "Sainzi" vakayambira nezve njodzi yekubuda kwehutachiona hutsva hweCorona virus, vachiregeredza dziviriro yechisikigo iyo jenasi rinopa kune vamwe vanhu.

Chidzidzo ichi chakaratidzawo kuti imwe yemhando dzemapuroteni anogadzirwa mumuviri uchishandisa "OAS1" gene inokwanisa kunyatsoona hutachiona hwe "SARS Cove 2", uye kudzivirira nzira yakaoma yechirwere.

kuparadza mavhairasi

Iyo OAS1 gene, inozivikanwa nesainzi, inotanga kutenderera kwemaitiro anomutsa ribonuclease L, enzyme inoparadza mavhairasi apinda musero uye inomutsa mhinduro dzekudzivirira kurwisa hutachiona.

Nekudaro, vanyori vezvidzidzo vanonongedza kuti zvinoenderana ne "mirairo" iri mu "OAS1", imwe yemhando mbiri dzakaenzana dzeprotein inoona hutachiona uye inokonzeresa mhinduro yekudzivirira muviri inogona kugadzirwa, pfupi "p42" kana kureba "p46", uye iyo yekupedzisira chete ndiyo inoshanda pakurwisa coronavirus, iyo yakakonzera denda, umo boka rakakosha remamorekuru rakanamirwa kwariri, rinofambisa kupindirana kweprotein ine cell membranes (aya anonzi maprotein prenylated).

Zvakare, chidzidzo ichi chakaratidza kukosha kwekucherechedza kuti pre-kutaura kwe "OAS1" kwakabatana nekudzivirirwa pamhando dzakakomba dze "Covid 19", uye izvi zvinoratidza kuti iyi immune system inoshanda sechinhu chakakosha chemhinduro yekudzivirira antiviral.

MuAfrica neEurope

Mhedzisiro iyi yakawanikwa zvichibva pakudzidza kwema genomes evanhu mazana mana nemakumi mapfumbamwe nevapfumbamwe vaive muchipatara vaine hutachiona hweCorona, muna mazana maviri negumi nevaviri vavo, mutumbi hauna kuburitsa "p499", uye pakati peboka iri, njodzi yerufu nekupinzwa mukuchengetwa kwakanyanya. rakanga rakakwirira nekamwe nehafu kupfuura rimwe boka.

Vakaratidzawo kuti havasi vese vane gene musiyano unogadzira iyo "p46" isoform, iyo inocherekedza zvakanaka zvinhu zvechimiro cheCorona virus, sezvo vaongorori vachiratidza kuti yakanyanya kuwanda pakati pevanhu vemuAfrica uye vanobva kune dzimwe nyika. kondinendi kupfuura chero kupi zvako, uye vakataura kuti Zvishoma pakati pevagari veguta guru rePeru, Lima (11% yezviitiko), uye kusvika pamwero mukuru pakati pevamiririri veIshan vanhu muNigeria (70% yezviitiko). Nepo veEurope vari pachinzvimbo chechipiri.

Masayendisiti ane maonero ekuti kukonzeresa kweruzhinji kuCovid-1 kunogona kuenderana chaizvo nekuwanda kweiyo "yakafanira" musiyano weOASXNUMX muhuwandu.

gimmick uye nekukurumidza kupararira

Sekusimbisa kwaProfessor Sam Wilson, mukuru weGlasgow Virus Research Center, zvinogoneka kuti hutachiona hweCovid-19 huchadzidza nekufamba kwenguva kunzvenga nzira yekudzivirira iyi, yayasati yambosangana nayo. Iyo OAS1 gene haipo mune inoisa yekutanga vatakuri ve "SARS-Cove-2", mabheti ebhiza.

Uye terevhizheni yeBritish "ITV" yakataura Wilson achiti tsvakiridzo "yakaratidza kuti coronavirus yakakonzera kubuda kweSARS muna 2003 yakadzidza kugara kure neOAS1, uchiona kuti shanduko nyowani kubva ku "SARS-Cove-2" kana iwe ukakwanisa. Kugona Iri zano rinogona kuwedzera hutachiona uye huchapararira zviri nyore pakati pevanhu vasina kubayiwa, izvo zvakaona kukosha kwekuenderera mberi kwekutarisa kwe "SARS-Cove-2" shanduko dzichangobva kubuda.

Iwe unobata sei nemunhu ane njere asina hanya newe?

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