Iska jir..daawada daaweysa kansarka, waxay keentaa kansarka

Daraasad lagu sameeyay Maraykanka ayaa lagu ogaaday in cilladaha hidde-sideyaasha ee ragga qaarkood ee qaba kansarka qanjirka 'prostate' ay saameyn ku yeelan karto jawaabahooda daawooyinka inta badan loo isticmaalo daaweynta cudurka. Cilmi-baarayaasha ku lugta leh daraasaddan oo dhawaan lagu daabacay wargeyska Clinical Investigation, ayaa aaminsan in natiijadoodu ay bixin karaan macluumaad muhiim ah oo lagu aqoonsanayo bukaannada ay u badan tahay inay fiicnaadaan marka lagu daweeyo daroogo kale.

Cilmi-baadhayaashu waxay ogaadeen in abirateron, oo ah dawada kansarka qanjirka 'prostate', ay soo saarto heerar sare oo ka mid ah product-ka testosterone-ka marka ay qaataan ragga qaba cudurrada sare ee isbeddelka hiddaha.

Qoraaga hormoodka ah ee daraasadda Dr. Nima Sharifi, MD, oo ka tirsan Machadka Cilmi-baarista Lerner ee Cleveland Clinic, ayaa hore u ogaatay in ragga qaba kansarka qanjirka 'prostate' ee gardarrada ah kuwaas oo isbeddel gaar ah ku leh hidda-wadaha HSD3B1 ay si aad ah uga hooseeyaan natiijooyinka daaweynta marka loo eego bukaannada aan haysan. Isbeddel hidde-side. Hidde-sidaha HSD3B1 wuxuu qeexayaa ensaymes kaas oo u oggolaanaya unugyada kansarka inay ku quudiyaan androgens adrenal. Insaymiskani aad buu u firfircoon yahay bukaanka qaba HSD3B1(1245C) isbeddelka hiddo-wadaha.

Dr. Sharifi iyo kooxdiisa oo ka tirsan Waaxda Kansarka Biology-ga, oo uu ku jiro qoraaga koowaad ee daraasaddan, cilmi-baare Dr. Muhammad Al Yamani, ayaa ogaaday in ragga qaba cilladdan hidde-sideyaasha ah ay metabolize abiraterone ka duwan yihiin kuwa dhiggooda ah iyada oo aan isbeddelkan hidde-sidaha ah.

Dr. Sharifi wuxuu muujiyay rajada uu ka qabo in natiijooyinkani ay horseedi doonaan "kor u qaadista awoodda aan ku daaweyneyno kansarka qanjirka 'prostate' iyadoo lagu salaynayo hiddaha gaarka ah ee koox kasta oo bukaan ah." Wuxuu yiri, "Daraasadyo badan ayaa loo baahan yahay, laakiin waxaan haynaa caddayn xooggan oo ah heerka Hidde-sidaha HSD3B1 wuxuu saameeyaa habka difaaca jirka." Dheef-shiid kiimikaad Abiraterone, iyo suurtogalnimada waxtarkeeda, iyo haddii tan la xaqiijiyo, waxaan rajeyneynaa inaan awoodno inaan aqoonsanno daawo kale oo waxtar leh oo waxtar u leh ragga qaba cilladaan hidde-sideyaasha."

Daawaynta dhaqameed ee kansarka qanjirka 'prostate', oo loo yaqaan "daaweynta yaraanta androgens," waxay xannibaysaa sahayda androgens unugyada quudiya iyaga oo u isticmaala inay koraan oo faafiyaan. Inkasta oo lagu guulaystay habkan daawaynta ee marxaladda hore ee cudurka, unugyada kansarku waxay mar dambe bilaabaan inay muujiyaan caabbinta habkan, taas oo u oggolaanaysa cudurku inuu u gudbo heer dhimasho ah oo loo yaqaan "kansarka qanjidhka qanjidhka ee u adkaysta", kaas oo unugyada kansarku ay bilaabayaan Ilaha kale ee androgens, qanjidhada adrenal. Abiraterone waxay ka celisaa androgens adrenal-ka unugyada kansarka.

Daraasaddan, cilmi-baarayaashu waxay baaris ku sameeyeen derivatives-yar-yar oo abiraterone ah kooxo dhowr ah oo rag ah oo u gudbay marxaladda castration-adkeysiga, waxayna ogaadeen in bukaannada qaba isbeddellada hidde-socodka ay leeyihiin heerar sare oo dheef-shiid kiimikaad ah oo loo yaqaan 5α-abiraterone. Dheef-shiid kiimikaadkani wuxuu khiyaaneeyaa soo-dhowrka androgen-ka isagoo kicinaya waddooyinka korriinka ee khatarta u ah kansarka. Waxa cajiib ah, soosaarkan dheef-shiid kiimikaad ee abirateron, oo asal ahaan loogu talagalay inuu joojiyo androgens, wuxuu u dhaqmi karaa sida androgens wuxuuna sababi karaa koritaanka unugyada kansarka qanjirka 'prostate'. Baaritaanka saameynta abirateron ee natiijooyinka kiliinikada ee bukaannada kansarka qanjirka 'prostate' ee castration u adkeysanaya waxay noqon doontaa tallaabada xigta ee muhiimka ah.

Dr. Eric Klein, oo madax ka ah machadka Glickman Urological and Kidney Institute ee Cleveland Clinic, ayaa sheegay in cilmi-baadhistu ay horumarisay fahamka saamaynta khalkhal ku leh ee isbeddellada hidde-sidaha ee hidda-wadaha HSD3B1, waxayna ku bishaaraynaysaa hab adag oo caafimaad oo lagu daweynayo ragga qaba kansarka qanjirka 'prostate'. "

Daraasaddan waxaa qayb ahaan taageeray deeqo ka yimid Machadka Kansarka Qaranka ee Waaxda Caafimaadka iyo Adeegyada Aadanaha ee Mareykanka iyo Mu'asasada Kansarka qanjirka 'prostate'. Dr. Howard Sully, oo ah kuxigeenka madaxa fulinta iyo madaxa sayniska ee hay'adda aan faa'iido doonka ahayn, ayaa ku tilmaamay daraasaddan inay gacan ka geysaneyso in la aqoonsado "dariiqa iska caabbinta cusub" ee dawada abiraterone ee sida caadiga ah loo isticmaalo daaweynta bukaannada qaba kansarka qanjirka 'prostate', iyo Mu'asasada Kansarka qanjirka 'prostate' ayaa mahad iyo han weyn u jeedinaysa Dr. "Waxaan rajeyneynaa in natiijooyinka Dr. Sharifi iyo kooxdiisu ay gacan ka geysan doonaan xulashada daaweynta hababka kala duwan ee bukaannada sita isbeddellada hidde-wadaha ee HSD3B1, si loo sii dheereeyo jawaabta bukaan-socodka, ” ayuu yiri.

Dr. Sharifi waxa uu haystaa Kursiga Qoyska Kendrick ee Cilmi-baarista Kansarka qanjirka 'prostate' ee Cleveland Clinic oo uu la agaasimo Xarunta Cleveland Clinic of Excellence ee Cilmi-baarista Kansarka Qanjirka 'prostate', wuxuuna ballamo wadajir ah la leeyahay Machadka Urology iyo Kelyaha ee Glickman iyo Machadka Kansarka Taussig. 2017, Dr. Sharifi waxaa la guddoonsiiyay "Tobanka Guul ee ugu Sarreysa ee Kiliinikada" Abaalmarinta Madasha Cilmi-baarista Clinical ee daahfurnaantiisii ​​hore ee hidda-wadaha HSD3B1.