Lumka..iyeza elinyanga umhlaza, libangela umhlaza

Uhlolisiso olwenziwa eUnited States lwafumanisa ukuba ukungaqhelekanga kwimfuza kwamanye amadoda anomhlaza wedlala lesinyi kunokuchaphazela indlela asabela ngayo kumayeza asetyenziswa ngokuqhelekileyo ukunyanga esi sifo. Abaphandi ababandakanyekayo kuphononongo, olusanda kupapashwa kwijenali yeClinical Investigation, bakholelwa ukuba iziphumo zabo zinokubonelela ngolwazi olubalulekileyo lokuchonga izigulane ezinokuthi zihambelane ngcono xa zinyangwa ngechiza elahlukileyo.

Abaphandi baye bafumanisa ukuba i-abiraterone, ichiza eliqhelekileyo lomhlaza we-prostate, livelisa amanqanaba aphezulu e-testosterone-efana neproduct xa ithathwa ngamadoda anesifo esihamba phambili anotshintsho oluthile lwemfuza.

Umbhali okhokelayo kwisifundo uGqr. Nima Sharifi, MD, weLerner Research Institute yaseCleveland Clinic, ngaphambili wafumanisa ukuba amadoda anomhlaza we-prostate anobundlobongela abanotshintsho oluthile kwi-HSD3B1 gene baneziphumo zonyango ezisezantsi kakhulu kunezigulane ezingenayo. I-HSD3B1 gene ifaka i-enzyme evumela iiseli zomhlaza ukuba zondle kwi-adrenal androgens. Le enzyme iyasebenza kakhulu kwizigulane ezine-HSD3B1 (1245C) yokuguqula i-gene.

UGqr. Sharifi kunye neqela lakhe kwiSebe le-Cancer Biology, kubandakanywa nombhali wokuqala wokufunda, umphandi uGqr Muhammad Al Yamani, wafumanisa ukuba amadoda anale ngxaki yofuzo i-metabolize i-abiraterone ngokwahlukileyo kunabalingane babo ngaphandle kolu tshintsho lwemfuza.

UGqr. Sharifi wavakalisa ithemba lakhe lokuba ezi ziphumo ziya kukhokelela “ekuphuculeni amandla ethu okunyanga umhlaza wedlala lesinyi ngokusekelwe kwimizila yemfuza yeqela ngalinye lesigulana.” Wathi, “Kufuneka uphando olungakumbi, kodwa sinobungqina obunamandla bokuba umzila wemfuza we-HSD3B1 uchaphazela inkqubo yomzimba yokuzikhusela.” I<em>Abiraterone metabolism, yaye ngokunokwenzeka ukusebenza kwayo, yaye ukuba oku kuqinisekisiwe, sinethemba lokuba siya kukwazi ukuchonga iyeza elilolunye elisebenzayo elinokuba luncedo ngakumbi kumadoda anale ngxaki yemfuza.”

Unyango lwesintu lomhlaza wedlala lesinyi, olubizwa ngokuba “lunyango lokuvimba i-androgen,” luvimba unikezelo lwee-androgens kwiiseli ezondla kuzo kwaye zizisebenzise ekukhuleni nasekusasazekeni. Ngaphandle kwempumelelo yale ndlela yonyango kwisigaba sokuqala sesi sifo, iiseli zomhlaza kamva ziqala ukubonisa ukuxhathisa le ndlela, zivumela isifo ukuba siqhubele phambili ukuya kwinqanaba elibulalayo elibizwa ngokuba "yi-castration-resistant cancer prostate," apho iiseli zomhlaza zibhenela kuyo. omnye umthombo we-androgens, i-adrenal glands. I-Abiraterone ivimba ezi adrenal androgens kwiiseli zomhlaza.

Kolu phononongo, abaphandi bavavanya i-abiraterone encinci ye-molecule kumaqela amaninzi amadoda aye aqhubela phambili kwinqanaba lokumelana ne-castration, kwaye afumanisa ukuba izigulane ezinokuguqulwa kofuzo zinezinga eliphezulu le-metabolite ebizwa ngokuba yi-5α-abiraterone. Le metabolite ikhohlisa i-androgen receptor ngokuvuselela iindlela zokukhula eziyingozi kumhlaza. Okumangalisayo kukuba, le mveliso ye-abiraterone ye-metabolism, eyenzelwe ukuthintela i-androgens, inokusebenza njenge-androgens kwaye ibangele ukukhula kweeseli zomhlaza we-prostate. Ukuphanda umphumo we-abiraterone kwiziphumo zeklinikhi kwi-castration-resistant-resistant cancer cancer izigulane ziya kuba linyathelo elilandelayo elibalulekileyo.

UDkt Eric Klein, umongameli weGlickman Urological and Kidney Institute eCleveland Clinic, uthe uphando "luqhubela phambili ukuqonda impembelelo ephazamisayo yokuguqulwa kofuzo kwi-HSD3B1 gene, kwaye ivakalisa indlela yonyango engqongqo yokunyanga amadoda anomdlavuza we-prostate."

Olu pho nonongo luxhaswe ngokuyinxenye ngezibonelelo ezivela kwiNational Cancer Institute yeSebe lezeMpilo lase-US kunye neeNkonzo zoLuntu kunye neProstate Cancer Foundation. UGqr. Howard Sully, usekela-mongameli olawulayo kunye negosa eliyintloko lezenzululwazi lombutho ongenzi nzuzo, uchaze uphando njengoncedo ekuboneni "indlela entsha yokumelana" neyeza i-abiraterone esetyenziswa ngokuqhelekileyo kunyango lwezigulane ezinomhlaza we-prostate, kunye neyeza. I-Prostate Cancer Foundation ibulela kunye nekratshi kuDkt. " uthe.

UDkt. Sharifi ubambe uSihlalo weNtsapho ka-Kendrick kwi-Prostate Cancer Research kwiKliniki yaseCleveland kwaye ulawula i-Cleveland Clinic Centre of Excellence kwi-Prostate Cancer Research, kwaye unomsebenzi odibeneyo kunye ne-Glickman Urology kunye ne-Kidney Institute kunye ne-Taussig Cancer Institute. Kwi-2017, uDkt. Sharifi wanikezelwa ngembasa ye "Top Ten Clinical Achievements" evela kwiForam yoPhando lweKliniki ngenxa yokufumanisa kwakhe kwangaphambili kwi-HSD3B1 gene.