Iprotheni yokuchasana nokuguga kunye nengqiqo-yokugcina

Iprotheni yokuchasana nokuguga kunye nengqiqo-yokugcina

Ngaphezulu kweminyaka engama-30 emva kokuba ichongiwe njenge "geneity engundoqo yokuphila," iprotheni ye-klotho isetyenziselwe ukunyusa umsebenzi wokuqonda kunye nokulwa nokuguga kwi-rhesus macaques, ivula indlela yezilingo zabantu, i-Atlas entsha ibika, ichaza ukuguga kweNdalo.

Ukulandela iziphumo zamva nje zovavanyo lwezilwanyana zaselabhoratri, iqela lehlabathi lezazinzulu lifumanise ukuba inkumbulo yokusebenza kunye nobuchule bokugqiba umsebenzi we-18 rhesus macaques, kunye nobudala obuphakathi kweminyaka engama-22 (elingana nama-65 kubomi bomntu), zaphuculwa xa zitofa Iprotheyini.

Phakathi kwabaphandi zizazinzulu ezivela kwiYunivesithi yaseCalifornia, eSan Francisco, kunye ne-Weill Neuroscience Institute, abaye bagxila kwizifundo zabo kwi-klotho kunye nomsebenzi wokuhlaziya ingqondo iminyaka engaphezu kwamashumi amahlanu.

Iziphumo zeenkawu zingcono kuneempuku

Kuphononongo, iinkawu kwafuneka ngokuphindaphindiweyo ukuzulazula lula kwaye kunzima mazes ukufumana ukutya, ukuze babone indlela kakuhle bakhumbula indlela ngqo.

Izilwanyana nazo zaziyiphinda loo misebenzi kwiiyure ezine kamva. Emva kokuginya iidosi zeklotho protein, izilwanyana zaselebhu zibonise umndilili we-6% kuphela yophuculo kwiimaze ezilula, ngelixa ziqhube ngcono ngama-20% kwimisebenzi enzima. Inkumbulo ibonakaliswe ukuba yonyuka kangangeeveki ezimbini ubuncinane. Okubangel 'umdla kukuba, ithamo belingaphantsi kunelinge leempuku.

Usapho lwe-klotho transmembrane protein luneentsapho ezintathu, kubandakanywa nezona zibizwa rhoqo kwi-alpha-klotho, eyachongwa kuphela ngo-1997 kwaye umsebenzi wayo awukaqondwa ngokupheleleyo. Kodwa kuye kwaboniswa ukuba kudlala indima enkulu ekugugeni, ukulawula iindlela ezininzi ezifana namanqanaba e-phosphate kunye nokubonakaliswa kwe-insulin.

Ukujikeleza imisonto yobomi bomntu

Iprotein, ethiywe ngothixokazi wamaGrike uKlotho, owasonta imisonto yobomi bomntu, ngokwemvelo iveliswa kwizintso kwaye iyancipha ngenxa yobudala.

Ukunqongophala kwayo kukwangunobangela we-atherosclerosis, uxinzelelo lwegazi oluphezulu, kunye nokukhukuliseka kwemithambo, phakathi kwezinye iimeko zempilo ezinxulumene nobudala.

Ngaphambili, uphononongo lubonise indlela iprotein ye-klotho ebonisa ngayo ukusebenza kwengqondo kuvavanyo kwiimpuku zelebhu, ukusuka kwindlela ukuzila ukutya okuchaphazela ngayo amanqanaba e-Klotho ukuya kwindlela utofelo-gazi lwe-plasma ukusuka kwizilwanyana ezincinci ukuya kwizilwanyana ezindala okubangele ukuvuselelwa kwemisipha.

UDina Dubal, omnye wabaphandi ababandakanyekayo kuphando lwangoku, uthelekisa iimvavanyo zengqondo kumava ehlabathi langempela njengesidingo sokukhumbula apho umntu eshiya imoto yakhe kwindawo yokupaka, okanye ekhumbula umtya wamanani, izakhono ezimbini ezihla kunye ubudala.

Ukwandisa ixesha "lempilo" elungileyo.

UGqr. Dubal, okwangoku ugqirha wophando kwi-Weill Institute of Neurosciences e-UCLA, uthi amandla okwandisa ubomi be-klotho afundwa iminyaka, nto leyo inokukhokelela ekubeni "impilo" ende kwaye wenze izinto ezikunceda ukuba uphile ngcono. .

Nangona uninzi luhlala lungaziwa malunga neendlela ezibandakanyekayo kwizakhono zokubuyisela iprotheni ye-klotho, uDkt.

Uqikelelo lukaMaguy Farah lwehoroscope yonyaka ka-2023