Unyango olusebenzayo kwizifo ezingapheliyo zemiphunga

Unyango olusebenzayo kwizifo ezingapheliyo zemiphunga

Uphononongo olutsha lufumanise ukuba iprotein evuselela amajoni omzimba womntu ukuyikhusela kwiintsholongwane ezithile, ebizwa ngokuba yi-TLR7, idlala indima ebalulekileyo ekongezeni kwesifo esingapheliyo semiphunga.

Oku kufunyanwa okungalindelekanga kunokukhokelela kwiindlela ezintsha zonyango zale meko enganyangekiyo, ngokutsho kwapapashwa yi-website ye-Atlas eNtsha, echaza iphephancwadi leNdalo yoNxibelelwano.

ukutshaya

Isifo semiphunga esingapheliyo (Cronic obstructive pulmonary disease) (COPD), ngamanye amaxesha kuthiwa yi-emphysema, sibangelwa kukutshaya icuba okanye ukuchanabeka kwizinto ezicaphukisayo.

Isenokonakalisa iingxowa zomoya kwimiphunga kwaye ibangele ukuvuvukala kunye nokuveliswa kwe-mucus engaphezulu, okwenza ukuphefumla kube nzima. I-COPD ayinyangeki nokunyangeka, kwaye unyango lukhawulelwe ekudambiseni iimpawu.

Abaphandi abavela kwiCentenary Institute kunye neYunivesithi yeTekhnoloji eSydney baqhube uphononongo malunga neendlela ezisemva kokwandiswa kwesifo semiphunga esingapheliyo, kwaye bafumanisa ukuba iToll-like protein receptor 7, ekwabizwa ngokuba yiTLR7, enceda ukukhusela umzimba womntu ngokuchaseneyo. iintlobo ezithile zeentsholongwane, zinendima ebalulekileyo kwaye zingalindelekanga.

Ukufunyanwa okumangalisayo

Kwelakhe icala, uZhang Liu, umphandi okhokelayo wophononongo, wathi: “Okothusayo kukuba, iziphumo zophononongo zibonisa amanqanaba aphezulu e-TLR7 kubantu abaneCOPD kunye neemodeli zovavanyo zeCOPD ezibandakanya iimpuku.

Intsapho ye-TLR yeeprotheyini idlala indima ebalulekileyo ekuqapheliseni iintsholongwane kunye nokwenza i-immunity innate. I-TLR7 iqaphela iintsholongwane ze-RNA ezinomsonto omnye ezifana nezo zibangela imasisi, umkhuhlane kunye ne-hepatitis C.

Abaphandi baphinde bavavanya i-transcriptomes kwii-biopsies zemiphunga ezithathwe kubanikeli abasempilweni kunye nabanikezeli beCOPD kumanqanaba ahlukeneyo obunzima besifo. Bachonge i-4269 yemfuza evezwe ngokwahlukileyo kumaqela amathathu emfuza ahambelana nokuphendula komzimba, ukulungiswa kwezicubu, kunye nokuhlelwa ngokutsha kwe-metabolic. Kuvela ukuba iprotheni ye-TLR7 yayiyinxalenye ye-immune response complex complex, eyayigqithise kakhulu kwi-COPD.

"Oku akulindelwanga kuba iindima ezaziwayo ze-TLR7 zikukhuselo lomzimba kunye nokukhuselwa ngokuchasene nokosuleleka kwizifo zokuphefumla," batsho abaphandi.

Umntu otshaya ipakethi enye yecuba

Kwaphawulwa ukuba iimpuku zitshintshwe ngokwemfuza ukuze zingabinaprotheyini ye-TLR7 kwaye zityhileke kumsi wecuba olingana nomsi otsalwa ngumntu otshaya ipakethi enye yecuba ngemini, zineemphysema encinci kunye nokulungiswa kwendlela yomoya, kunye nokuphucula ukusebenza kwemiphunga kunye ne-apoptosis. imiphunga. Ukunika i-iquimod, eyaziwa ngokuvula i-TLR7, kwiimpuku ezisempilweni ezivezwe kumsi wecuba nazo zongeze iingxaki zemiphunga.

"Iiseli zeMast zidlala indima ebalulekileyo ekwandiseni iCOPD ngokuqalisa kunye nokuqhubela phambili ukudumba ngaphakathi kwezicubu ezithambileyo zemiphunga, zenza ukuphefumla nzima kwizigulana," utshilo umphandi uLiu, ephawula ukuba kufunyaniswe ukuba "amanqanaba aphezulu eTLR7 anyusa umsebenzi weseli yemast." " Oku kukhokelela ekubeni iingxaki zemiphunga zibe mandundu.”

Abaphandi babonise ithemba lokuba iziphumo zabo zingakhokelela kunyango lweCOPD Umphandi uLiu uthe: "Ukuvala i-TLR7 ngamachiza ekujoliswe kuwo kunokuba yindlela entsha yonyango ethembisayo yeCOPD, imeko enzima yemiphunga engenakunyangwa okwangoku." ".

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