Qaphela..umuthi owelapha umdlavuza, udala umdlavuza

Ucwaningo olwenziwa e-United States lwathola ukuthi ukungalungi kwezakhi zofuzo kwamanye amadoda anomdlavuza wendlala yesinye kungase kuthonye indlela asabela ngayo emithini esetshenziswa ngokuvamile yalesi sifo. Abacwaningi abahilelekile ocwaningweni, olusanda kushicilelwa kujenali ye-Clinical Investigation, bakholelwa ukuthi imiphumela yabo ingase inikeze ulwazi olubalulekile lokuhlonza iziguli okungenzeka ziphile kangcono uma zelashwa ngomuthi ohlukile.

Abacwaningi bathole ukuthi i-abiraterone, isidakamizwa esivamile somdlavuza wendlala yesinye, ikhiqiza amazinga aphezulu e-byproduct efana ne-testosterone uma ithathwa amadoda anesifo esithuthukile anoshintsho oluthile lofuzo.

Umbhali oholayo ocwaningweni uDkt. Nima Sharifi, MD, we-Lerner Research Institute yaseCleveland Clinic, ngaphambilini uthole ukuthi amadoda anomdlavuza we-prostate aggressive abe noshintsho oluthile kuzakhi zofuzo ze-HSD3B1 anemiphumela yokwelashwa ephansi kakhulu kuneziguli ezingenayo.Ushintsho lwezakhi zofuzo. Isakhi sofuzo se-HSD3B1 sifaka i-enzyme evumela amangqamuzana omdlavuza ukuthi adle ama-adrenal androgens. Le enzyme isebenza ngokweqile ezigulini ezinoshintsho lofuzo lwe-HSD3B1(1245C).

UDkt. Sharifi nethimba lakhe ophikweni lwe-Cancer Biology, okuhlanganisa nombhali wokuqala walolu cwaningo, umcwaningi uDkt. Muhammad Al Yamani, bathole ukuthi amadoda analokhu kuphazamiseka kofuzo asebenzisa i-abiraterone ngendlela ehlukile kunozakwabo ngaphandle kwalolu shintsho lofuzo.

UDkt. Sharifi wazwakalisa ithemba lakhe lokuthi le miphumela izoholela “ekuthuthukiseni ikhono lethu lokwelapha umdlavuza wendlala yesinye ngokusekelwe ezakhini zofuzo zeqembu ngalinye lesiguli.” Wathi, “Kudingeka ucwaningo olwengeziwe, kodwa sinobufakazi obuqinile bokuthi isimo isakhi sofuzo se-HSD3B1 sithinta isimiso somzimba sokuzivikela ezifweni.” I-Abiraterone metabolism, futhi ngokunokwenzeka nokusebenza kwayo, futhi uma kuqinisekisiwe, sithemba ukuthi sizokwazi ukuhlonza esinye isidakamizwa esisebenzayo esingase siphumelele kakhudlwana emadodeni analokhu kungavamile kwezakhi zofuzo.”

Ukwelashwa kwendabuko komdlavuza wendlala yesinye osethuthukile, okubizwa ngokuthi "i-androgen deprivation therapy," kuvimbela ukuhlinzekwa kwama-androgens kumaseli adla kuwo futhi awasebenzise ukuze akhule futhi asabalale. Naphezu kokuphumelela kwale ndlela yokwelapha ekuqaleni kwalesi sifo, amangqamuzana omdlavuza kamuva aqala ukubonisa ukumelana nale ndlela, okwenza lesi sifo sidlulele esigabeni esibulalayo esibizwa ngokuthi “umdlavuza wendlala yesinye” lapho amangqamuzana omdlavuza ephendukela khona. omunye umthombo we-androgens, izindlala ze-adrenal. I-Abiraterone ivimba lawa ma-adrenal androgens kumaseli omdlavuza.

Kulolu cwaningo, abacwaningi bahlola ama-abiraterone ama-molecule amancane emaqenjini amaningana amadoda aye aqhubekela phambili esiteji sokumelana ne-castration, futhi bathola ukuthi iziguli ezinokuguqulwa kofuzo zinezinga eliphezulu le-metabolite ebizwa ngokuthi i-5α-abiraterone. Le metabolite ikhohlisa i-androgen receptor ngokuvuselela izindlela zokukhula eziyingozi kumdlavuza. Ngokuphawulekayo, le byproduct ye-abiraterone metabolism, ekuqaleni eyenzelwe ukuvimbela i-androgens, ingase isebenze njengama-androgens futhi ibangele ukukhula kwamangqamuzana omdlavuza wendlala yesinye. Ukuphenya umthelela we-abiraterone emiphumeleni yomtholampilo yeziguli ezinomdlavuza we-prostate ukumelana ne-castration kuzoba isinyathelo esilandelayo esibalulekile.

UDkt. Eric Klein, umongameli we-Glickman Urological and Kidney Institute eCleveland Clinic, uthe lolu cwaningo "luthuthukisa ukuqonda umphumela ophazamisayo wezinguquko zofuzo kufuzo lwe-HSD3B1, futhi lumemezela indlela yokwelapha eqinile yokwelashwa kwamadoda anomdlavuza we-prostate othuthukisiwe. ."

Lolu cwaningo lusekelwe ngokwengxenye izibonelelo ezivela ku-National Cancer Institute yoMnyango Wezempilo Nezinsizakalo Zabantu wase-US kanye ne-Prostate Cancer Foundation. UDkt. Howard Sully, iphini likamongameli omkhulu kanye nesikhulu esiphezulu sesayensi yenhlangano engenzi nzuzo, uchaze lolu cwaningo njengolusiza ukuhlonza “indlela entsha yokumelana” nesidakamizwa i-abiraterone esivame ukusetshenziswa ekwelapheni iziguli ezinomdlavuza wendlala yesinye, kanye Ukubonga nokuziqhenya kweProstate Cancer Foundation kuDkt. “Sithemba ukuthi okutholwe uDkt. Sharifi nethimba lakhe kuzosiza ekukhetheni izindlela zokwelapha ezihlukene zeziguli eziphethe izinguquko ezithile zofuzo kufuzo lwe-HSD3B1, ukuze kwandiswe ukusabela komtholampilo, " uthe.

UDkt. Sharifi uphethe uSihlalo Womndeni wakwa-Kendrick ku-Prostate Cancer Research eCleveland Clinic futhi uqondisa i-Cleveland Clinic Centre of Excellence ku-Prostate Cancer Research, futhi unezikhathi ezihlanganyelwe ne-Glickman Urology and Kidney Institute kanye ne-Taussig Cancer Institute. Ngo-2017, uDkt. Sharifi uthole i-"Top Ten Clinical Achievement Award" evela ku-Clinical Research Forum ngokuthola kwakhe kwangaphambilini kofuzo lwe-HSD3B1.