Okokuqala, uhlobo lwesifo sikashukela sohlobo 3 akufanele ludidaniswe nesifo sikashukela sohlobo 3c, okuyisifo esihluke ngokuphelele. Kodwa "uhlobo lwesifo sikashukela sohlobo 3" luxhunyaniswa nokumelana ne-insulin ebuchosheni, ngokusho kwe-Live Science.

Isiguli okutholakala ukuthi asikwazi ukumelana ne-insulin ngokuvamile kusho ukuthi sine-prediabetes noma sinesifo sikashukela sohlobo 2. Kodwa ososayensi basola ukuthi kungabangela namangqamuzana ezinzwa ebuchosheni ukuba aswele i-glucose, edingekayo ukuze kusebenze kahle, okungase kubangele izimpawu ze-Alzheimer's. isifo..

Nakuba isifo sikashukela sohlobo lwesithathu singesona isimo sezempilo esiqashelwa ngokusemthethweni, ngo-3 uDkt. Suzanne de la Monte kanye noDkt Jack Wands waseBrown University basikisela ukuthi isifo i-Alzheimer’s singabizwa ngokuthi “uhlobo 2008 lwesifo sikashukela” ngenxa yokuhlotshaniswa kwaso okuqinile nokungazweli kwe-insulin.

Ukumelana ne-insulin kungaba imbangela enkulu yokuwohloka komqondo, njengoba ukuntuleka kwe-glucose metabolism ebuchosheni kunomthelela ezimpawini ezifana nokulahlekelwa inkumbulo kanye nokuncipha kokwahlulela kanye namakhono okucabanga.

Isifo sikashukela sohlobo 3 asilona igama elaziwa ngokwezempilo futhi akuyona into odokotela abayisebenzisela ukuxilonga. Kodwa ukumelana ne-insulin nokuncipha kokusayina kwe-insulin ebuchosheni kungase kubambe iqhaza ekuthuthukisweni kwesifo i-Alzheimer's. Ingasaphathwa ukuthi ingozi yesifo i-Alzheimer iphezulu kakhulu kubantu abanesifo sikashukela sohlobo 2. Ngakho-ke, igama elithi "uhlobo lwesifo sikashukela sohlobo 3" liye lasetshenziswa ngokuhlanganyela ngabanye emkhakheni ukuze kucaciswe lokhu kuxhumana.

Ucwaningo, olwanyatheliswa kuyi-Lancet Neurology, lwahlobanisa isifo sikashukela nempilo ebuchosheni futhi lwaphakamisa ukuthi ukwelashwa okubuyisela ukusebenza kwe-insulin yobuchopho kunganikeza izinzuzo zokwelapha kulabo abanesifo i-Alzheimer's.

UDkt. William Fry, uchwepheshe ocwaningweni lwesifo i-Alzheimer’s, uchaza ukuthi lesi sifo sibangela ukwehla komqondo ezigulini, echaza ukuthi “isifo i-Alzheimer’s yisifo esiwohlozayo sobuchopho esibangela ngaphezu kuka-60% wamacala okuwohloka komqondo. Kuphawulwa ukulahlekelwa inkumbulo, ikakhulukazi izinkumbulo zesikhashana noma zakamuva, ukuncipha kwengqondo noshintsho ekuziphatheni, konke okuba kubi kakhulu ngokuhamba kwesikhathi.”

UDkt. Tarek Mahmoud, onguDokotela kanye noMqondisi wezokwelapha kwaConcepto Dignostics wengeza ngokuthi “Isifo sikashukela sohlobo 3 sihlukile kuhlobo loku-1 nolwesibili lwesifo sikashukela, okuholela ekutheni izinga likashukela egazini linyuke kakhulu ngenxa yezinkinga zehomoni ebizwa nge-insulin. Abanye ososayensi basikisela ukuthi ukungasebenzi kahle kwe-insulin ebuchosheni kubangela ukuwohloka komqondo futhi kusetshenziswe isifo sikashukela sohlobo 2 njengegama lokuchaza isifo i-Alzheimer’s, okuyisimo esiqhubekayo sezinzwa esiyimbangela evame kakhulu yokuwohloka komqondo.”

Izimpawu kanye nokuxilongwa

UDkt. Mahmoud uchaza ukuthi nakuba “isifo sikashukela sohlobo 3” singesona isifo esingokomthetho, odokotela bangaxilonga isifo i-Alzheimer’s, esithinta imisebenzi eminingi yobuchopho kancane kancane phakathi neminyaka eminingi, ethi: “Ngokuvamile izinkinga ezincane zenkumbulo ziwuphawu lokuqala.” . Izimpawu eziqondile kakhulu zingabandakanya ukudideka, ukuhlela ubunzima, ukudideka, ukudideka, kanye nezinguquko zobuntu.”

Izimpawu zakuqala ukuya kwezimaphakathi zesifo i-Alzheimer zifaka:
• ukuntula ukwahlulela
• ukulahlekelwa inkumbulo
• ukudideka
ukuyaluza/ukukhathazeka
• Izinkinga zokufunda, ukubhala nezinombolo
• Ubunzima bokwazi umndeni nabangane
• Imicabango edidekile.

Izimpawu zivame ukukhula kuze kube yilapho iziguli zingakwazi ukugwinya, zingakwazi ukulawula amathumbu futhi ekugcineni zife.Isiguli esinesifo i-Alzheimer siyafa ngemva kokuhlushwa i-aspiration pneumonia, ngenxa yokuthi ukudla noma uketshezi luthuthela emaphashini esikhundleni somoya ngenxa yezinkinga zokugwinya.

UDkt. Frey uthi ukuxilongwa okungcono kakhulu kwesifo i-Alzheimer kwenziwa udokotela wezinzwa ojwayelene ne-neurodegenerative memory disorders, ephawula ukuthi “izinqubo zokuxilonga zihlanganisa ukuthatha umlando ophelele wesiguli, ukuhlolwa kwegazi, ukuthwebula izithombe zobuchopho, ukuhlola i-neuropsychological, njll. nezinye izifo ezingase ziholele esifweni se-Alzheimer.”

Izinkinga zokumelana ne-insulin

Ukubuyekezwa kwesayensi kokumelana ne-insulin ku-Frontiers in Neuroscience kuphawula ukuthi i-insulin ixhumanisa izimo ezimbalwa ndawonye, ​​njengokukhuluphala, ukuwohloka komqondo nesifo sikashukela, futhi incoma ukusetshenziswa okungaba khona kwemithi elwa nesifo sikashukela ukwelapha ukuwohloka komqondo. Ukubuyekezwa kuphinde kuhlole ukuxhumana phakathi kokuwohloka komqondo kanye nomthwalo ophakeme wokuhlukanisa, okungumthwalo osuka ekucindezelekeni, ezenzakalweni zempilo nezinye izinselele zemvelo.

UDkt. Mahmoud uchaza ukuthi nakuba isayensi ingacacile ngembangela eqondile yesifo i-Alzheimer’s, inhlanganisela yezici ingase ibe nendima, njengoba “kukholelwa kabanzi ukuthi izinguquko zezinzwa ezihambisana nokuguga, kanye nezici zofuzo.” Imvelo, nendlela yokuphila.

UDkt. Mahmoud uchaza ukuthi “iminyaka yobudala iyisici esiyingozi kunazo zonke esaziwa njengengozi yesifo i-Alzheimer’s ngenxa, phakathi kwezinye izinto, i-atrophy, okungukuthi ukulahleka kwezicubu ezingxenyeni ezithile zobuchopho, okusho ukuthi ubuchopho bungashwabana, bube buthaka, noma bube buthakathaka ngokuphelele. ulahlekile.”

Kodwa uDkt. Fry ukwenza kucace ukuthi ukuguga okuvamile akuyona ukuphela kwengozi ehlobene nokuthuthukiswa kwesifo i-Alzheimer's, echaza ukuthi "ukuguga kuyingozi enkulu yesifo i-Alzheimer's, kodwa isifo se-Alzheimer asiyona ingxenye evamile yokuguga. Umlando womndeni wesifo i-Alzheimer kanye nezinguquko zofuzo nakho kungandisa ingozi, kodwa abantu abangenawo umlando womndeni we-Alzheimer's bangaba nesifo i-Alzheimer's. Umlando we-TBI emaphakathi ungakhuphula kakhulu ingozi yesifo i-Alzheimer's.

Isifo sikashukela sohlobo 2 siphindaphinda ingozi yesifo i-Alzheimer's, ngokusekelwe eqinisweni lokuthi kokubili isifo sikashukela kanye nesifo i-Alzheimer's, kukhona ukuntuleka kokubonisa i-insulin.

Ukulahlekelwa amandla kumaseli obuchopho

UDkt. Frey uchaza ukuthi esifweni i-Alzheimer's, ukuntuleka kokubonisa i-insulin kwenzeka ebuchosheni futhi kuholela ekulahlekelweni kwamandla emangqamuzaneni obuchopho, futhi ngaleyo ndlela kube ngaphandle kwamasignali e-insulin eyanele, ushukela wegazi awudluliselwe emangqamuzaneni obuchopho, echaza ukuthi “ ukulahlekelwa amandla emangqamuzaneni obuchopho kusho ukuthi ubuchopho abunawo. Iyakwazi ukwenza inkumbulo nokusebenza kwengqondo ngokujwayelekile, futhi ayikwazi ukukhiqiza izingxenye zamangqamuzana obuchopho adingekayo ukuze kuthathelwe indawo lawo aguga ngokuhamba kwesikhathi okuholela ekuwohlokeni kobuchopho. ingqondo uqobo.”

UDkt Fry uthi ukuphila okungenampilo okuhlanganisa nokungazivocavoci, ukungadli ukudla kahle nokungalali kahle nakho kungandisa amathuba okuba nesifo i-Alzheimer's.

Ukwelashwa ngamakhala

Ucwaningo lukaDkt. Fry luyingqalabutho emkhakheni wokumelana ne-insulin nesifo i-Alzheimer's. Kulo nyaka, ukhiphe ukubuyekezwa kwesayensi kwe-Pharmaceuticals no-Indira Rao kanye nozakwabo begomela ukuthi izindawo zobuchopho lapho ukumuncwa kweglucose egazini kuphazamiseka khona kubantu abanesifo i-Alzheimer's futhi echaza ukuthi ukwelashwa kwe-insulin ye-intranasal kungasiza ekwehleni kwe-cerebral glucose metabolism, okungukuthi. Isakhiwo esivame ukutholakala kubantu abanesifo i-Alzheimer's, isifo sika-Parkinson, nezinye izinkinga ze-neurodegenerative.

“Ngenxa yokuthi ukushoda kwe-insulin enganele kunomthelela ekulahlekelweni kwamandla amangqamuzana obuchopho kubantu abanesifo i-Alzheimer, i-insulin efakwa emakhaleni yaqale yahlongozwa njengokwelashwa kwesifo i-Alzheimer cishe eminyakeni engu-22 edlule,” kusho uDkt. Fry. Ukuphathwa kwe-insulin emakhaleni kuqondise ubuchopho eduze kwemizwa ebangela ukuhogela ngaphandle kokushintsha amazinga e-insulin noma ushukela egazini.

Kodwa nakuba izivivinyo zemitholampilo zibonise ukuthi i-insulin engahlanyisi ye-intranasal yandisa amandla engqamuzana lobuchopho futhi ithuthukisa inkumbulo kubantu abadala abanempilo evamile, kanye nalabo abanenkinga yokuqonda kancane noma isifo i-Alzheimer's, idinga ukuthuthukiswa okwengeziwe nokuhlolwa ukuze kufakazelwe ngokwanele ukuphepha nokusebenza kwayo ngaphambi kwesikhathi. ingakwazi ukuyicabangela ukuze igunyazwe ngokomthetho futhi iyenze itholakale.

Ungasivikela kanjani isifo sikashukela sohlobo 3

Ukubuyekezwa kwesayensi kwe-Alzheimer's kuphakamisa ukuthi ukuzindla kungasiza ekuvimbeleni isifo i-Alzheimer's ngoba kunciphisa umthwalo ohlukile, oye waxhunyaniswa nokuthuthukiswa kokuphazamiseka kwengqondo okuningana. Imizuzu engu-12 nje yokuzindla kwe-Kirtan Kriya ngosuku iye yaboniswa ukuthuthukisa ikhwalithi yokulala, ukunciphisa ukucindezeleka nokukhathazeka, ukulawula izakhi zofuzo kanye nezakhi zofuzo zamasosha omzimba, kanye nokuthuthukisa amazinga e-insulin nezakhi zofuzo ezilawula i-glucose.

UDkt. Mahmoud uthi, “Ukuphila ngendlela enempilo kungaholela ezingozini ezincishisiwe, kodwa akunakwenzeka ukunqoba izinguquko ezithinta izinzwa ezihlobene nobudala nezici zofuzo. Isifo senhliziyo siye sahlotshaniswa nokuba sengozini eyengeziwe yokuba nesifo i-Alzheimer’s, ngakho ukudla ukudla okulinganiselayo, ukuqiniseka ukuthi uthola imizuzu engu-150 yokuvivinya umzimba ngesonto, futhi ukuyeka ukubhema kuyinzuzo.”

ukudla kwaseMedithera

Uhlelo lokudla kanye nohlelo lokudla lwe-vegan lwezinsuku eziyi-7 lunemibono eminingi yokukusiza ukuthi udle ukudla okunomsoco.

UDkt. Fry uyavuma ukuthi ukuphila okunempilo okuvamile kuyisinyathelo esihlakaniphile emsebenzini wokugwema isifo i-Alzheimer, esitusa ukuthi “ukulondoloza indlela yokuphila enempilo, kuhlanganise nokuvivinya umzimba njalo nokugwema ukulimala ekhanda ngokubopha ibhande lapho ushayela noma ugibele izimoto nokugqoka isigqoko. ngenkathi uzivocavoca Ukudla ukudla okunempilo nokuhlala umatasa nomphakathi kungasiza ukunciphisa ingozi yesifo i-Alzheimer's."