Iprotheni elwa nokuguga kanye neyokugcina ingqondo

Iprotheni elwa nokuguga kanye neyokugcina ingqondo

Eminyakeni engaphezu kwengu-30 ngemva kokuba ikhonjwe “njengesakhi sofuzo esibalulekile sokuphila isikhathi eside,” iphrotheni ye-klotho iye yasetshenziswa ukuthuthukisa ukusebenza kwengqondo nokulwa nokuguga kuma-rhesus macaques, ivula indlela yokuhlolwa kwabantu, kubika i-Atlas Entsha, icaphuna Ukuguga Kwemvelo.

Ngemva kwemiphumela yakamuva evela ekuhlolweni kwezilwane zaselabhorethri, ithimba lamazwe ngamazwe lososayensi lithole ukuthi inkumbulo yokusebenza namandla okuqeda umsebenzi we-rhesus macaques engu-18, anesilinganiso sobudala seminyaka engu-22 (okulingana neminyaka engu-65 ekuphileni komuntu), athuthukiswa lapho ejova. amaprotheni. ingubo.

Phakathi kwabacwaningi kukhona ososayensi abavela eNyuvesi yaseCalifornia, eSan Francisco, nase-Weill Neuroscience Institute, abaye bagxila ezifundweni zabo ku-klotho kanye nomsebenzi wokuqonda ovuselelayo iminyaka engaphezu kwamashumi amahlanu.

Imiphumela yezinkawu ingcono kunaleyo yamagundane

Esifundweni, izinkawu kwakudingeka zizulazule ngokuphindaphindiwe ama-mazes alula futhi anzima ukuze zithole ukudla, ukuze zibone ukuthi zikhumbula kahle kangakanani indlela eqondile.

Izilwane nazo zaphinda imisebenzi ngemva kwamahora amane. Ngemva kokungenisa imithamo ye-klotho protein, izilwane zaselabhu zabonisa isilinganiso sokuthuthuka okungama-6% kuphela kuma-maze alula, kuyilapho zenze kangcono ngama-20% emisebenzini enzima. Inkumbulo ikhonjiswe ukuthi iyanda okungenani amasonto amabili. Kuyathakazelisa ukuthi umthamo wawuphansi uma kuqhathaniswa nokuhlolwa kwamagundane.

Umndeni wamaphrotheni e-klotho transmembrane wakhiwe imindeni emithathu engaphansi, okuhlanganisa nevame ukubizwa ngokuthi i-alpha-klotho, eyatholwa kuphela ngo-1997 futhi umsebenzi wayo namanje ongakaqondwa ngokugcwele. Kodwa kukhonjiswe ukuthi kunendima enkulu ekugugeni, ukulawula izindlela eziningi ezifana namazinga e-phosphate kanye nokusayina kwe-insulin.

Ukuphotha imicu yempilo yomuntu

Iphrotheni, eqanjwe ngonkulunkulukazi wamaGreki uKlotho, owaphotha intambo yokuphila komuntu, ngokwemvelo ikhiqizwa ezinso futhi iyancipha ngenxa yobudala.

Ukushoda kwayo futhi kuyimbangela ye-atherosclerosis, umfutho wegazi ophakeme, nokuguguleka kwemithambo, phakathi kwezinye izimo eziningi zempilo ezihlobene nobudala.

Ngaphambilini, ucwaningo lwalubonise ukuthi i-klotho protein expression ithuthukisa kanjani ukusebenza kwengqondo ekuhlolweni kwamagundane elebhu, kusukela ekutheni ukuzila ukudla ngezikhathi ezithile kwawathinta kanjani amazinga e-Klotho kuya ekutheni ukumpontshelwa kwe-plasma kusuka ezilwaneni ezincane kuya kwezindala kubangele ukuvuselelwa kwemisipha.

U-Dina Dubal, ongomunye wabacwaningi ababambe iqhaza ocwaningweni lwamanje, uqhathanisa izivivinyo zokuqonda nolwazi lwezwe langempela njengesidingo sokukhumbula lapho umuntu eshiya imoto yakhe endaweni yokupaka, noma ukukhumbula uchungechunge lwezinombolo, womabili amakhono ancipha iminyaka yobudala.

Ukwandisa isikhathi "sempilo" enhle.

UDkt Dubal, osengudokotela wocwaningo e-Weill Institute of Neurosciences e-UCLA, uthi amandla okwandisa impilo ye-klotho kufundwa iminyaka, okungaholela ekubeni "nempilo" ende futhi wenze izinto ezikusiza uphile kangcono. .

Nakuba kuningi okungaziwa mayelana nezinqubo ezihilelekile kumakhono okubuyisela e-klotho amaprotheni, uDkt.

Izibikezelo ze-horoscope zika-Maguy Farah zonyaka ka-2023