Ingabe ukutholakala kwe-Alzheimer kungenzeka ngaphambi kokutheleleka?

Ingabe ukutholakala kwe-Alzheimer kungenzeka ngaphambi kokutheleleka?

Lapho befuna indlela ephephile nephumelelayo yokubikezela isifo se-Alzheimer, abacwaningi baseSweden bathola i-molecule kashukela egazini leziguli ezithintekile.

Lapho kuhlanganisa ukuhlolwa kwenkumbulo okulula nokuhlaziywa kofuzo, ithimba labacwaningi lakwazi ukubikezela ukuqala kwesimo eminyakeni eyishumi kusengaphambili ngezinga elikhulu lokunemba.

Iphrothokholi esanda kutholwa ingajoyina ezinye izindlela zokuxilonga zesifo i-Alzheimer's, ukusiza ososayensi bathole lesi sifo ngaphambi kokuba izimpawu ziqale futhi bathathe izinyathelo zokumisa ukuqhubeka kwaso.

izindlela ezilula

Futhi kubonakala sengathi ososayensi bayasondela cishe nsuku zonke ukuze bathole izindlela ezintsha zokubikezela ukuqala kwesifo i-Alzheimer's, ngokwalokho iwebhusayithi ye-New Atlas ebikiwe nge-Alzheimer's & Dementia. Imizamo ebikwe ngaphambilini yokusebenzisa izinto ezigqokwayo ukuze kulandelelwe amaphethini okunyakaza ahambisana nalesi simo, kusetshenziswa ama-algorithms angahlaziya izikena ze-positron emission tomography (PET) ukuze kutholwe izimpawu zesifo kusasele iminyaka, nokuhlaziya okuthole izifunda ezingama-75 ze-genomic ezihlobene nesifo.

Ukuhlola uketshezi lomzimba nakho kungabonisa isithembiso njengendlela yokubikezela. Kodwa ngenxa yokuthi ukususa uketshezi lwe-cerebrospinal kuhlale kuyisiphakamiso esiyingozi, abacwaningi, kuhlanganise nososayensi baseKarolinska Institute eSweden, bazama ukuthola izindlela zokuthola lesi sifo ngokusebenzisa ukuhlolwa kwegazi okulula kakhulu.

amaprotheni

Phambilini, abacwaningi bathole ukuthi izinto ezinoshukela ezibizwa ngama-glycans ezitholakala ku-cerebrospinal fluid zingahlotshaniswa nokuba khona kwamaphrotheni e-tau emzimbeni. Amazinga aphezulu e-tau protein engajwayelekile ebuchosheni angezinye zezimpawu eziyinhloko zesifo i-Alzheimer's, ngakho ukusithola kusenesikhathi emzimbeni kungaba yindlela yokubikezela ukuqala kwalesi simo.

Eqinisweni, ithimba lithole ukuthi abantu abanamazinga afanayo e-glycans ne-tau banethuba eliphindwe kabili lokuthuthukisa isifo i-Alzheimer kunalabo abangenazo izimpawu.

glycans egazini

Kulolu cwaningo olusha, abacwaningi bathola ukuthi ama-glycans, okuwushukela oyinkimbinkimbi egazini noma ama-molecule asekelwe ushukela agqoke amaprotheni, nawo akhona egazini.

Ngokuhlanganisa lolu lwazi nokuhlaziywa kofuzo nokuhlolwa kwenkumbulo, bakwazi ukubikezela ukuqala kwesifo i-Alzheimer ngokunemba okungafika kumaphesenti angu-80, kuze kube yiminyaka eyi-10 ngaphambi kokuba kubonakale izimpawu zokulahlekelwa inkumbulo.

Inkambu engahloliwe ngokuqhathaniswa

"Indima yama-glycans, izakhiwo ezakhiwe ngama-molecule kashukela, iyindawo engakaze ihlolwe ocwaningweni lokuwohloka komqondo," kusho umlobi wokuqala uRobin Chu we-Karolinska Institutet. Imiphumela yocwaningo ibonise ukuthi amazinga egazi e-glycans ashintsha kusenesikhathi ngesikhathi sokukhula kwesifo, okungase kusho ukuthi ingozi yesifo i-Alzheimer ingabikezelwa ngokuhlolwa kwegazi nokuhlolwa kwenkumbulo kuphela.

Njengesinyathelo esilandelayo, abacwaningi bazofunda amasampula egazi engeziwe afakwe kukho kokubili ocwaningweni lwesiSwidi kanye nezifundo zokuguga ezenziwa phesheya. Ithimba labacwaningi lizophinde lisebenze ukuze lenze lokho okutholakele kuzilungiselelo zomtholampilo.

U-Schedeen Weiss, umbhali oholayo walolu cwaningo, uthe unethemba lokuthi "ama-glycans egazini azobonakala ewusizo ezindleleni ezikhona zokuhlola abantu isifo se-Alzheimer's okuzokwenza ukuthi lesi sifo sisheshe sitholakale."

Izibikezelo ze-horoscope zika-Maguy Farah zonyaka ka-2023