A yi hattara..magungunan da ke magance cutar daji, yana haifar da cutar kansa

Wani bincike da aka gudanar a kasar Amurka ya gano cewa cutar da wasu mazan da ke dauke da cutar sankara ta prostate na iya shafar yadda suke mayar da martani ga magungunan da aka saba amfani da su wajen magance cutar. Masu binciken da suka shiga cikin binciken, wanda aka buga kwanan nan a cikin mujallar Clinical Investigation, sun yi imanin cewa sakamakonsu na iya ba da mahimman bayanai don gano majinyata waɗanda za su fi kyau idan aka bi da su da wani magani daban.

Masu bincike sun gano cewa abiraterone, maganin ciwon daji na prostate na yau da kullum, yana samar da nau'i mai yawa na kwayoyin halitta irin na testosterone lokacin da maza masu cututtuka masu tasowa suka dauka wanda ke da wani canji na kwayoyin halitta.

Marubucin binciken Dokta Nima Sharifi, MD, na Cibiyar Bincike na Lerner na Cleveland Clinic, a baya ya gano cewa maza masu fama da ciwon daji na prostate wadanda ke da wani canji na musamman a cikin kwayoyin HSD3B1 suna da ƙananan sakamakon magani fiye da marasa lafiya ba tare da shi ba. Canjin kwayoyin halitta. Halin HSD3B1 yana ɓoye wani enzyme wanda ke ba da damar ƙwayoyin kansa su ciyar akan androgens adrenal. Wannan enzyme yana wuce gona da iri a cikin marasa lafiya tare da canjin HSD3B1 (1245C).

Dokta Sharifi da tawagarsa a Sashen Nazarin Halittar Kansa, ciki har da marubucin farko na binciken, mai bincike Dokta Muhammad Al Yamani, ya gano cewa maza masu wannan matsalar ta dabi'ar halitta suna metabolize abiraterone daban-daban fiye da takwarorinsu ba tare da wannan canji na kwayoyin halitta ba.

Dokta Sharifi ya bayyana fatansa cewa wadannan sakamakon za su haifar da "inganta ikon mu na magance ciwon daji na prostate bisa la'akari da ƙayyadaddun kwayoyin halitta na kowane rukuni na marasa lafiya." Ya ce, "Ana buƙatar ƙarin bincike, amma muna da kwakkwaran shaida cewa matsayi na Halin HSD3B1 yana shafar tsarin garkuwar jiki.” Abiraterone metabolism, kuma mai yiyuwa ingancinsa, kuma idan an tabbatar da hakan, muna fatan za mu iya gano wani ingantaccen magani na madadin wanda zai iya yin tasiri a cikin maza masu wannan rashin lafiyar kwayoyin halitta.”

Maganin gargajiya na ciwon daji na prostate mai ci gaba, wanda ake kira "maganin rashin lafiyar androgen," yana toshe samar da androgens zuwa kwayoyin da ke ciyar da su da amfani da su don girma da yadawa. Duk da nasarar wannan hanyar magani a farkon cutar, daga baya kwayoyin cutar kansa sun fara nuna juriya ga wannan hanya, suna ba da damar cutar ta ci gaba zuwa wani mataki mai mutuwa da ake kira "Cancer-resistant prostate cancer", inda kwayoyin cutar kansa ke shiga. madadin tushen androgens, da adrenal gland. Abiraterone yana toshe waɗannan adrenal androgens daga ƙwayoyin kansa.

A cikin wannan binciken, masu bincike sun bincika ƙananan ƙwayoyin ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar ƙwayar cuta da ake kira 5α-abiraterone. Wannan metabolite yana yaudarar mai karɓar isrogen ta hanyar haɓaka hanyoyin haɓaka waɗanda ke da haɗari ga ciwon daji. Abin sha'awa shine, wannan samfurin abiraterone metabolism, wanda aka ƙera asali don hana androgens, zai iya zama kamar androgens kuma ya haifar da ci gaban kwayoyin cutar kansar prostate. Binciken tasirin abiraterone akan sakamakon asibiti a cikin masu fama da ciwon gurguwar ƙwayar cuta zai zama muhimmin mataki na gaba.

Dokta Eric Klein, shugaban Cibiyar Nazarin Urological da Kidney ta Glickman a Cleveland Clinic, ya ce binciken "ci gaban fahimtar tasirin canje-canjen kwayoyin halitta a cikin kwayar halittar HSD3B1, kuma ya ba da sanarwar tsauraran tsarin likita don kula da maza masu fama da ciwon daji na prostate. ."

An tallafa wa wannan binciken a wani bangare ta tallafi daga Cibiyar Ciwon daji ta Kasa na Sashen Lafiya da Sabis na Jama'a na Amurka da Gidauniyar Ciwon daji ta Prostate. Dokta Howard Sully, mataimakin shugaban zartarwa kuma babban jami'in kimiyya na kungiyar mai zaman kanta, ya bayyana binciken da cewa yana taimakawa wajen gano "sabuwar hanyar juriya" ga maganin abiraterone da aka saba amfani da shi wajen kula da masu fama da ciwon daji na prostate, da kuma Godiya da alfahari da Gidauniyar Prostate Cancer Foundation ga Dr. "Muna fatan cewa binciken Dr. Sharifi da tawagarsa za su taimaka wajen zabar nau'o'in hanyoyin kwantar da hankali ga marasa lafiya da ke dauke da wasu canje-canje na kwayoyin halitta a cikin kwayoyin HSD3B1, don tsawaita amsawar asibiti. ” in ji shi.

Dokta Sharifi yana riƙe da Shugaban Iyali na Kendrick a Binciken Ciwon Cutar Prostate a Cleveland Clinic kuma yana jagorantar Cibiyar Kula da Lafiya ta Cleveland a cikin Binciken Ciwon Ciwon Prostate, kuma yana da alƙawura tare da Glickman Urology and Kidney Institute da Taussig Cancer Institute. A cikin 2017, Dr. Sharifi ya sami lambar yabo ta "Nasarar Nasarar Asibitoci Goma" daga Cibiyar Nazarin Clinical don binciken da ya yi a baya na HSD3B1 gene.