Iindaba ezimbi ezivela kwiCorona kwabo batyebe kakhulu

Kwiinkcukacha, uGqirha uYesu Eugenio Sosa Garcia, onoxanduva lwamatyala abalulekileyo kwigumbi labagula kakhulu kwisibhedlele iMedica Sur kwiSixeko saseMexico, uqinisekisile ukuba eyona nto ibalulekileyo kubo bonke amatyala asemngciphekweni we-Covid-19 awayinyangayo. ibikukutyeba kakhulu.

Wongeze, ngokutsho kwiphephancwadi lezonyango i<em>Nature, ukuba yena noogxa bakhe bavavanye amanani kwasekuqaleni kobhubhani baza bafumanisa ukuba isiqingatha sabaguli abangama-32 abangeniswe kwigumbi labagula kakhulu babetyebe ngokugqithiseleyo.

Ngaphandle kwethemba lokuba isitofu sokugonya intsholongwane esakhulayo siza kuveliswa kungekudala, kodwa eMexico nakwamanye amazwe amaninzi anenani elandayo labantu abanezikhombisi zobunzima bomzimba ophezulu (BMIs), abanye abaphandi boyika ukuba isitofu sokugonya sisenokungabi yi-panacea ogqirha kunye nayo. Abaguli banethemba

Umthombo omtsha ongalindelekanga wosulelo lwe-corona

Ulingo lwezonyango

EUnited States, uDonna Ryan, ofunda ngokutyeba ngokugqithiseleyo kwiZiko loPhando ngeBiomedical Research eliseBaton Rouge, eLouisiana, elisePennington, eLouisiana, uDonna Ryan uthi: “Izitofu zokugonya, eziluncedo kwezinye iimeko ezimbalwa, zidla ngokungasebenzi. Oku kucebisa ukuba isitofu sokugonya se-COVID-19 sinokunganikeli ukhuseleko kangangoko bekulindelwe.

Nangona abaphandi abakwazanga ukuqiniseka ukuba ukutyeba kakhulu kuyakuchaphazela ukusebenza kogonyo, kusenokwenzeka ukuba ezinye iindlela ziyakufunyanwa ukuchasana neengxaki ukuba ziyavela. Kodwa izazinzulu zikwavakalise inkxalabo yokuba izilingo zeklinikhi zisenokungakwazi ukubona ezo ngxaki kwangoko okanye kumanqanaba okuqala.

Iingozi ziya zisanda

Kwakhona e-China, kwacaca kwangethuba ekuqhambukeni kwesifo se-Covid-19 ukuba ukutyeba kwandisa umngcipheko wosulelo, xa ugqirha wezifo zesifo u-Lin Shu kwiYunivesithi yase-Sun Yat-Sen e-Guangzhou wayehlalutya idatha ye-wave yokuqala yesibetho kubhubhani. ilizwe, uqaphele ukuvela kwepateni kwimodeli nganye nganye, ucebisa ukuba i-BMI ibisoloko ingumba ocacileyo kubunzima bamatyala e-COVID-19.

Izizathu ezinokwenzeka

Xa wayefaka izifundo zakhe kwijenali yezemfundo ngoMatshi ka-2020, abahleli abaphetheyo ukukhupha le jenali bambongoza ukuba anxibelelane namagosa e-WHO kwaye abalumkise malunga noko akufumanisileyo.

Ukusukela ngoko, iziphumo zezifundo zesayensi kwihlabathi liphela ziye zavela, ezifikelele kwisigqibo esifanayo, sokuba abo batyebe kakhulu kunokwenzeka ukuba basweleke xa benesifo se-Covid-19 xa kuthelekiswa nabo banobunzima obuqhelekileyo, nkqu nakwilizwe jikelele. ubukho bezinto ezifana nesifo seswekile.Kwaye kuthathelwe ingqalelo uxinzelelo lwegazi oluphezulu.

izicubu ze-adipose

Ukongeza, ukutyeba kakhulu kunokonyusa iziphumo ze-metabolic zosulelo lwe-coronavirus. Izicubu ze-Adipose zivakalisa amanqanaba aphezulu e-ACE2 (i-angiotensin-converting enzyme 2) esetyenziswa yi-coronavirus ukuhlasela iiseli. UGqr. Gianluca Iacobilis, ugqirha we-endocrinologist kwiYunivesithi yaseMiami eFlorida uthi: "Izicubu ze-adipose zibonakala zisebenza njengendawo yokugcina i-coronavirus entsha.

ukudumba okungapheliyo

Kodwa ziimpembelelo kukhuselo lomzimba ezikhathaza kakhulu abanye abaphandi, kuba ukutyeba kakhulu kunokubangela ukudumba okungapheliyo okukwibakala elisezantsi, ekucingelwa ukuba kunegalelo kumngcipheko wokwanda kweemeko ezifana nesifo seswekile kunye nesifo sentliziyo. Ngenxa yoko, abaphandi bacetyisa, abantu abatyebe kakhulu banokuba namanqanaba aphezulu eeproteni ezilawula amajoni omzimba, kubandakanya ne-cytokines.

Iimpendulo ze-immune ezikhutshwe zii-cytokines zingonakalisa izicubu ezisempilweni kwezinye iimeko ezinzima ze-COVID-19, utshilo uMilena Sokolowska, ofunda i-immunology kunye nezifo zokuphefumla kwiDyunivesithi yaseZurich eSwitzerland. Ngokumangalisayo, uDkt Sokolowska uchaza ukuba, imeko eqhubekayo yokuvuselela umzimba, okanye ukudinwa okuqhubekayo, kunokuphazamisa ezinye iimpendulo ze-immune, kubandakanywa impendulo ye-T-cell enokubulala ngokuthe ngqo iiseli ezisulelekileyo.

ixesha elide

Ubungqina bokuqala bucebisa ukuba usulelo lwe-SARS-CoV-2 luqhubeka kangangeentsuku ezintlanu kwizigulana ezityebe kakhulu kunakwabo babhityileyo, utshilo uDaniel Drucker, ugqirha we-endocrinologist kunye nogqirha kwisibhedlele saseMount Sinai eToronto eCanada.

amathumbu kunye nemiphunga microorganisms

Ngelixa uSokolowska wongeza ukuba ukutyeba kakhulu kukhokelela kumaqela asezantsi nangaphantsi ahlukeneyo eentsholongwane emathunjini, impumlo kunye nemiphunga, kunye neengxaki ze-metabolic function xa kuthelekiswa nabantu ababhityileyo. Uchaza ukuba i-microbes yamathumbu inokuchaphazela indlela amajoni omzimba asabela ngayo ukuxhathisa iintsholongwane okanye ukusetyenziswa komzimba kwezitofu, ecaphula kulo mongo into ebhengezwe ngabaphandi, kulo nyaka uphelileyo, umzekelo, ukuba utshintsho kwi-gut microbiome ngenxa yokuthatha amayeza okubulala iintsholongwane kuchaphazela kakubi Ukusabela komzimba kwisitofu sokugonya somkhuhlane.

I-13% yabantu abadala ehlabathini

Ngokweenkcukacha zamva nje zeWorld Health Organisation, malunga ne-13% yabantu abadala emhlabeni batyebe kakhulu. Unjingalwazi uRyan walatha kuphononongo lwezitofu zokugonya umkhuhlane, ihepatitis B kunye nomgada, ezibonise iimpendulo ezisezantsi kwabo batyebe kakhulu kunabo babhityileyo. UNjingalwazi uShaw uthi: "Kwiimeko zokugonywa komkhuhlane, akuzange kuzuze iziphumo ezilungileyo kwizigulane ezityebileyo."

Ukunyusa iidosi

Kungenzeka ukuba iindlela ziya kufunyanwa ukuhlawulela ukusilela kwisiphumo sokugonya kwizigulane ezityebe ngokugqithiseleyo, njengoko kunjalo ngempumelelo yemigudu yabaphandi yokuphucula amazinga okuphendula isitofu phakathi kwabantu abadala. UNjingalwazi Ryan uthi ukunika abantu abatyebe ngokugqithiseleyo iidosi ezongezelelweyo zesitofu sokugonya yinto enye enokwenzeka. "Mhlawumbi izithonga ezintathu endaweni yezimbini, okanye idosi enkulu, kodwa oogqirha akufuneki babambezele besithi isitofu sokugonya asizukusebenza."

Isikhalo sokulumkisa

Ekugqibeleni, uDrucker waphawula, umhlaba unokufuna ukulinda idatha evela kwizifundo zeklinikhi ukucacisa imephu yendlela, kodwa ukulinda kunokuba yi-nerve-wracking. UGqr. Sosa Garcia kunye nabanye banethemba lokuba umanyano phakathi kwe-COVID-19 kunye nokutyeba kakhulu kunokunyanzela oorhulumente abathile kunye neenkqubo zokhathalelo lwezempilo ukuba bajongane neengxaki ezikhulayo zokutyeba kumazwe abo, besithi: "Ukuba ubuligosa lezempilo likarhulumente kwaye uqaphele ukuba 40 I-% yabemi basemngciphekweni omkhulu, Le datha ngumnxeba wokuvuka. "