Umuthi omusha welapha umdlavuza ojwayeleke kakhulu!!

Futhi lisekhona ithemba elikhula usuku nosuku, ukuthola ikhambi ongaliphuthelwa yileso sifo esiyingozi, futhi imiphumela yakamuva yocwaningo kube wucwaningo lwakamuva lwaseBrithani, oluveze ukuthi isibulala-magciwane esivame ukusetshenziselwa ukwelapha izifo zamathumba kanye nesifo sohudo singasiza ukwelapha isifo sohudo. izinhlobo eziyingozi kakhulu zomdlavuza wesikhumba we-melanoma.

Ucwaningo lwenziwe abacwaningi e-Medical Research Council Institute of Genetics and Molecular Medicine eNyuvesi yase-Edinburgh, eBrithani, futhi bashicilela imiphumela yabo, namuhla, ngoMsombuluko, kumagazini wesayensi i-Cell Chemical Biology.

Ithimba lenze ucwaningo ukuze lithole ukusebenza kwe-nifuroxazide, isibulala-magciwane esisetshenziswa njengesibulala-magciwane samathumbu esibanzi ukwelapha isifo sohudo, i-gastroenteritis kanye ne-colitis, kubantu abadala nasezinganeni ezineminyaka engaphezu kweyisithupha.

Abacwaningi bachaze ukuthi izimila ze-melanoma zingase ziphendule ekwelashweni kwamanje kwalesi sifo, kodwa ezinye aziphenduli futhi umdlavuza wesikhumba umelana nezidakamizwa, ezisekela ukukhula nokusabalala kwesimila.

Ucwaningo lwangaphambilini lubonise ukuthi amangqamuzana omdlavuza amelana nemithi akhiqiza ikakhulukazi i-enzyme ebizwa ngokuthi i-ALDH1.
. Ukuthola izindlela zokubhekana nalawa mangqamuzana omdlavuza ayingozi kakhulu, ithimba lizame ngesithako esisebenzayo i-nifuroxazid ukuze limise ukukhiqizwa kwale enzyme futhi licekele phansi amangqamuzana ayikhiqizayo emazingeni aphezulu.

Ithimba lafaka amasampula e-melanoma yomuntu kumagundane labe seliwaphatha nge-nifuroxazide, futhi abacwaningi bathola ukuthi le mithi elwa namagciwane ikhetha ukubulala amaseli e-tumor ayekhiqiza amazinga aphezulu e-enzyme (ALDH1), futhi ayizange ilimaze ezinye izinhlobo zamangqamuzana.

Umcwaningi oholayo uDkt Liz Patton uthe: 'Ngeke kube khona ikhambi elilodwa lokukhomba izimila ze-melanoma, ngoba umehluko phakathi kwamathumba kusho ukuthi kudingeka ukwelashwa okuhlangene.

"Ucwaningo lwethu selukhombisile ukuthi lesi sibulala-magciwane, esisetshenziswa kakhulu ukukhomba amagciwane amathumbu, singahlasela futhi sibulale amangqamuzana omdlavuza."

Uveze ukuthi kuhle ukuthi lesi sidakamizwa sigunyazwe ukuthi sisetshenziswe kubantu, kodwa njengoba singadalelwenga ukuthi sibe wumuthi womdlavuza, kusamele sazi ukuthi siphephile yini futhi siyasebenza ezigulini ezinomdlavuza, isibonelo, ukuthi singafinyelela yini. umdlavuza emzimbeni nokuthi Iyini imithamo edingekayo, ukuze isebenze kangcono kumaseli omdlavuza, esizokwazi ezifundweni ezizayo.

I-melanoma, noma i-melanoma, iwuhlobo lomdlavuza wesikhumba oluyingozi kakhulu, futhi ikhula emangqamuzaneni akhiqiza i-melanin, i-pigment eyenza isikhumba sibe nombala.

Umdlavuza wesikhumba wuhlobo lomdlavuza oluvame kakhulu e-United States, kanti ngokwezibalo zeNational Cancer Institute, babalelwa ku-74 abantu abasha abatholakala benomdlavuza wesikhumba kuleli ngo-2015.